https://scholars.lib.ntu.edu.tw/handle/123456789/475258
標題: | Molecular epidemiology of plasma oncoproteins in vinyl chloride monomer workers in Taiwan | 作者: | Luo J.-C.J. TSUN-JEN CHENG CHUNG-LI DU Wang J.-D. |
公開日期: | 2003 | 出版社: | Elsevier | 卷: | 27 | 期: | 2 | 起(迄)頁: | 94-101 | 來源出版物: | Cancer Detection and Prevention | 摘要: | Aims: To determine the presence of Asp13-p21-ki-ras oncoprotein and p53 oncoprotein in the plasma of vinyl chloride monomer (VCM)-workers in Taiwan. Methods: We used enhanced chemiluminescence (ECL) western blotting to detect Asp13-p21-ki-ras and ELISA to detect mutant p53 protein (p53-Ag) and anti-p53 antibodies (p53-Ab) in the plasma of VCM-exposed workers. Results: Twenty-five out of 251 (10%) VCM-workers were positive for Asp13-p21-ki-ras in plasma, but 0 out of 36 controls were positive. There were 15 out of 95 (15.8%) plasma-positives among the more highly exposed (>480 ppm-month) workers and 10 out of 156 (6.4%) plasma-positives among the lesser exposed (?480 ppm-month). Compared to the unexposed controls, age and drinking adjusted odds ratios (95% CI) were 1.2 (0.1, 9.8) in the lower exposed workers, and 4.8 (0.8, 28) in the higher exposed workers, and there was a significant linear trend between exposure and plasma positivity (P = 0.001). Thirty-three out of 251 (13.2%) VCM-workers were positive for the p53 over-expression (10% with positive p53-Ag and 2.8% with positive p53-Ab). There was a significant association between cumulative VCM exposure concentration and positive p53 expression (P = 0.032) among VCM-workers after adjusting for age, hepatitis, drinking and smoking status. Conclusions: Asp13-p21-ki-ras oncoprotein and p53 over-expression (p53-Ag or p53-Ab) can be found in the plasma of VCM-workers in Taiwan, and a significant dose-response relationship exists between plasma oncoproteins expression and VCM exposure. ? 2003 International Society for Preventive Oncology. Published by Elsevier Science Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037254263&doi=10.1016%2fS0361-090X%2803%2900021-7&partnerID=40&md5=bba94b2cbe52e04316de6660e70274d8 https://scholars.lib.ntu.edu.tw/handle/123456789/475258 |
ISSN: | 0361-090X | DOI: | 10.1016/S0361-090X(03)00021-7 |
顯示於: | 環境職業醫學科 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。