https://scholars.lib.ntu.edu.tw/handle/123456789/475266
標題: | Plasma p53 protein and anti-p53 antibody expression in vinyl chloride monomer workers in Taiwan | 作者: | Luo J.-C.J. Liu H.-T. TSUN-JEN CHENG CHUNG-LI DU Wang J.-D. |
公開日期: | 1999 | 卷: | 41 | 期: | 6 | 起(迄)頁: | 521-526 | 來源出版物: | Journal of Occupational and Environmental Medicine | 摘要: | Vinyl chloride (VC) workers are known to be at risk for development of angiosarcoma of the liver (ASL), a rare tumor. Previously, a study of p53 gene mutations in tumors of VC-exposed workers found that 50% of liver angiosarcomas contained such mutations. Mutant p53 oncoprotein and anti-p53 antibodies can also be found in the sera of ASL patients and VC-exposed workers without cancer. Workers in Taiwan have also been exposed to VC, and some have contracted liver tumors. In this study, we used enzyme-linked immunosorbent assays to detect mutant p53 protein and anti-p53 antibodies in the plasma of VC-exposed workers in Taiwan. Thirty-three of 251 (13.2%) VC- workers tested positive for the p53 overexpression (10% with positive mutant p53 protein and 3.6% with positive anti-p53) in their plasma, but only 2 of 36 controls (5.6%) tested positive (2.8% with positive mutant p53 protein and 2.8% with positive anti-p53). There was a significant association between cumulative VC exposure concentration and positive p53 expression (P = O. 032) among VC workers after we adjusted for age, hepatitis, drinking, and smoking status. In summary, P53 overexpression (mutant p53 protein or anti-p53 antibody) can be found in the plasma of VC workers in Taiwan, and a significant dose-response relationship exists between plasma p53 overexpression and VC cumulative exposure concentration. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033003337&doi=10.1097%2f00043764-199906000-00020&partnerID=40&md5=086f7a19c747787b0bcc12f03a0e2e40 https://scholars.lib.ntu.edu.tw/handle/123456789/475266 |
ISSN: | 1076-2752 | DOI: | 10.1097/00043764-199906000-00020 | SDG/關鍵字: | antibody; protein p53; protein p53 antibody; unclassified drug; vinyl chloride; adult; alcohol consumption; angiosarcoma; article; chemical industry; controlled study; dose response; enzyme linked immunosorbent assay; gene mutation; gene overexpression; genotoxicity; hepatitis b; human; liver toxicity; major clinical study; male; occupational exposure; occupational hazard; protein blood level; protein expression; smoking habit; Taiwan; Adult; Aged; Antibodies; Biological Markers; Carcinogens; Cohort Studies; Hemangiosarcoma; Humans; Liver Neoplasms; Male; Middle Aged; Occupational Exposure; Taiwan; Tumor Suppressor Protein p53; Vinyl Chloride |
顯示於: | 環境職業醫學科 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。