https://scholars.lib.ntu.edu.tw/handle/123456789/475311
標題: | Prolonged postprocedural outbreak of Mycobacterium massiliense infections associated with ultrasound transmission gel | 作者: | ARISTINE CHENG WANG-HUEI SHENG Huang Y.-C. HSIN-YUN SUN Tsai Y.-T. Chen M.-L. Liu Y.-C. YU-CHUNG CHUANG SHU-CHIEN HUANG Chang C.-I. LUAN-YIN CHANG Huang W.-C. PO-REN HSUEH CHIEN-CHING HUNG YEE-CHUN CHEN SHAN-CHWEN CHANG |
公開日期: | 2016 | 出版社: | Elsevier B.V. | 卷: | 22 | 期: | 4 | 起(迄)頁: | 3820 | 來源出版物: | Clinical Microbiology and Infection | 摘要: | Postprocedural infections by Mycobacterium abscessus complex are increasing worldwide, and the source and route of transmission are infrequently identified. Here the extension of a previous clustering of paediatric patients with surgical site infections due to a single strain of the subspecies M. massiliense is reported. The investigation was conducted at a 2200-bed teaching hospital in Taiwan and included microbial surveillance of the environment (water, air, equipment and supplies) and a case-control study. We performed molecular identification and typing of the isolates by a trilocus sequencing scheme, confirmed by multilocus sequencing typing and pulsed-field gel electrophoresis. We investigated 40 patients who developed postprocedure soft tissue or bloodstream infections by M. massiliense (TPE101) during a 3-year period. Thirty-eight patients were identified at hospital A, and one newborn and her mother were identified at hospital B (185 km from hospital A). A case-control study identified the association of invasive procedures (adjusted odds ratio, 9.13) and ultrasonography (adjusted odds ratio, 2.97) (both p <0.05) with acquiring the outbreak strain. Isolates from the cases and unopened bottles of ultrasound transmission gel were all of strain ST48 and indistinguishable or closely related by pulsed-field gel electrophoresis. After replacement of contaminated gel, no new cases were detected during 18 months' follow-up. This investigation identified the use of contaminated gel as the common source causing an outbreak on a larger scale than had been recognized. Our findings halted production by the manufacturer and prompted revision of hospital guidelines. ? 2016 European Society of Clinical Microbiology and Infectious Diseases. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84963725764&doi=10.1016%2fj.cmi.2015.11.021&partnerID=40&md5=63ad5373ba1f8c29635cb62e21efcd45 https://scholars.lib.ntu.edu.tw/handle/123456789/475311 |
ISSN: | 1198-743X | DOI: | 10.1016/j.cmi.2015.11.021 | SDG/關鍵字: | adolescent; adult; aged; Article; bloodstream infection; case control study; child; clinical article; controlled study; female; follow up; gel; human; infant; invasive procedure; male; middle aged; multilocus sequence typing; mycobacteriosis; Mycobacterium massiliense; Mycobacterium massiliense infection; newborn; priority journal; pulsed field gel electrophoresis; retrospective study; soft tissue infection; surgical infection; ultrasound transmission gel; adverse effects; atypical Mycobacterium; classification; drug contamination; echography; epidemic; genetics; genotype; isolation and purification; microbiology; Mycobacterium Infections, Nontuberculous; Surgical Wound Infection; Taiwan; teaching hospital; very elderly; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Disease Outbreaks; Drug Contamination; Electrophoresis, Gel, Pulsed-Field; Female; Genotype; Hospitals, Teaching; Humans; Infant; Infant, Newborn; Male; Middle Aged; Multilocus Sequence Typing; Mycobacterium Infections, Nontuberculous; Nontuberculous Mycobacteria; Retrospective Studies; Surgical Wound Infection; Taiwan; Ultrasonography |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。