https://scholars.lib.ntu.edu.tw/handle/123456789/475332
標題: | Efficacy and safety of intermittent hemodialysis in infants and young children with inborn errors of metabolism | 作者: | I-JUNG TSAI WUH-LIANG HWU SHU-CHIEN HUANG NI-CHUNG LEE EN-TING WU YIN-HSIU CHIEN Tsau Y.-K. |
公開日期: | 2014 | 卷: | 29 | 期: | 1 | 起(迄)頁: | 111-116 | 來源出版物: | Pediatric Nephrology | 摘要: | Background: Intermittent hemodialysis (IHD) is the most efficient form of renal replacement therapy (RRT) for removing toxic substances from patients' bodies. However, the efficacy and safety of IHD in infants and young children with inborn errors of metabolism are still not clear. Methods: This retrospective study included patients with urea cycle disorders, maple syrup urine disease, and methylmalonic acidemia who received IHD or non-IHD RRT at our hospital between 2001 and 2012 to remove ammonia, leucine, or methylmalonic acid. Both the efficacy and safety of the RRT were evaluated. Results: Thirty-five courses of RRT, including 25 courses of IHD and ten courses of non-IHD RRT, for 15 patients were included in the analysis. Before 2006, non-IHD RRT procedures, including peritoneal dialysis (PD) and continuous venous-venous hemofiltration (CVVH), were the most often used; from 2006 onwards IHD was used. There was one procedure-unrelated death. Catheter penetration occurred in one course of IHD. The efficacy data revealed that both the median duration of dialysis and the median 50 % toxin reduction time were shorter in IHD than in non-IHD RRT. Conclusions: In infants and young children with inborn errors of metabolism, IHD is safe and more efficient than non-IHD RRT at removing toxins. ? 2013 IPNA. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84890557375&doi=10.1007%2fs00467-013-2609-2&partnerID=40&md5=bb493ee80a711429d7ce72241b407343 https://scholars.lib.ntu.edu.tw/handle/123456789/475332 |
ISSN: | 0931-041X | DOI: | 10.1007/s00467-013-2609-2 | SDG/關鍵字: | ammonia; heparin; leucine; methylmalonic acid; article; child; clinical article; comparative study; continuous hemodialysis; continuous hemofiltration; female; hemodialysis; hemofiltration; human; inborn error of metabolism; infancy; infant; loading drug dose; male; maple syrup urine disease; medical record review; methylmalonic acidemia; peritoneal dialysis; preschool child; priority journal; renal replacement therapy; retrospective study; safety; school child; urea cycle disorder; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Metabolism, Inborn Errors; Renal Dialysis; Retrospective Studies |
顯示於: | 醫學系 |
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