https://scholars.lib.ntu.edu.tw/handle/123456789/475877
標題: | Carotid artery intima-media thickness, carotid plaque and coronary heart disease and stroke in Chinese | 作者: | KUO-LIONG CHIEN TA-CHEN SU JIANN-SHING JENG Hsu, Hsiu-Ching WEI-TIEN CHANG MING-FONG CHEN Lee, Yuan-Teh Hu, Frank B. |
公開日期: | 17-十月-2008 | 卷: | 3 | 期: | 10 | 起(迄)頁: | e3435 | 來源出版物: | PLoS ONE | 摘要: | Background: Our aim was to prospectively investigate the association between carotid artery intima-media thickness (IMT) as well as carotid plaque and incidence of coronary heart disease (CHD) and stroke in Chinese, among whom data are limited. Methods and Findings: We conducted a community-based cohort study composed of 2190 participants free of cardiovascular disease at baseline in one community. During a median 10.5-year follow up, we documented 68 new cases of coronary heart disease and 94 cases of stroke. The multivariate relative risks (RRs) associated with a change of 1 standard deviation of maximal common carotid IMT were 1.38 (95% confidence interval [CI], 1.12-1.70) for CHD and 1.47 (95% CI, 1.28-1.69) for stroke. The corresponding RRs with internal carotid IMT were 1.47 (95% CI, 1.21-1.79) for CHD and 1.52 (95% CI, 1.31-1.76) for stroke. Carotid plaque measured by the degree of diameter stenosis was also significantly associated with increased risk of CHD (p for trend<0.0001) and stroke (p for trend<0.0001). However, these associations were largely attenuated when adjusting for IMT measurements. Conclusions: This prospective study indicates a significant association between carotid IMT and incidence of CHD and stroke in Chinese adults. These measurements may be useful for cardiovascular risk assessment and stratification in Chinese. ? 2008 Chien et al. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/475877 https://www.scopus.com/record/display.uri?eid=2-s2.0-55649087094&doi=10.1371%2fjournal.pone.0003435&origin=inward&txGid=e5e6592b457ef8fc6c797f5554a7864b |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0003435 | SDG/關鍵字: | adult; artery intima proliferation; article; atherosclerotic plaque; cardiovascular risk; carotid artery; carotid artery obstruction; Chinese; cohort analysis; community; female; follow up; human; incidence; ischemic heart disease; major clinical study; male; risk assessment; statistical analysis; stroke; aged; Asian; carotid artery obstruction; common carotid artery; coronary artery disease; echography; intima; middle aged; pathology; prospective study; risk factor; stroke; tunica media; Adult; Aged; Asian Continental Ancestry Group; Carotid Artery, Common; Carotid Stenosis; Cohort Studies; Coronary Disease; Female; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Stroke; Tunica Intima; Tunica Media |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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