https://scholars.lib.ntu.edu.tw/handle/123456789/475884
標題: | Genetic association study of APOA1/C3/A4/A5 gene cluster and haplotypes on triglyceride and HDL cholesterol in a community-based population | 作者: | KUO-LIONG CHIEN MING-FONG CHEN Hsu, Hsiu-Ching TA-CHEN SU WEI-TIEN CHANG CHII-MING LEE Lee, Yuan-Teh |
關鍵字: | Apolipoprotein A1/C3/A4/A5; Haplotype; HDL cholesterol; Triglyceride | 公開日期: | 二月-2008 | 卷: | 388 | 期: | 1-2 | 起(迄)頁: | 78-83 | 來源出版物: | Clinica Chimica Acta | 摘要: | Background: Polymorphism of apolipoprotein A1/C3/A4/A5 gene cluster affected lipid profiles in general population. We reported 6 polymorphisms, APOA1 -75G>A, APOA1 83C>T, APOC3 3175C>G, APOC3 3206G>T, APOA4 127A>G, and APOA5 553G>T in APOA1/C3/A4/A5 gene and the haplotype structures on triglyceride and HDL traits among ethnic Chinese. Results: Overall, there were statistically significant differences in the distribution of APOA1 -75G>A and APOA5 +553G>T genotypes comparing cases with control subjects. For the APOA1 -75 SNP, a lower risk of triglyceride/HDL among subjects with A/A genotype compared with those with the G/G genotype (odds ratio, OR = 0.39, 95% CI 0.16-0.92, P = 0.04). However, the risk magnitude reduced after multivariate adjustments. For continuous traits, we found that only in APOA5 +553 T allele carriers showed a significant higher triglyceride and a significant lower HDL cholesterol level than subjects with APOA5 +553 G/G genotypes. There were significant differences in overall haplotype frequencies between case and control subjects (P < 0.001). Conclusion: There is an important role of APOA1/C3/A4/A5 gene polymorphisms and haplotypes in the development of high triglyceride/HDL ratio in Chinese. © 2007. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/475884 https://www.scopus.com/record/display.uri?eid=2-s2.0-37249076490&doi=10.1016%2fj.cca.2007.10.006&origin=inward&txGid=4d7af385d3c5d7cf5d75e19d810cdf0a |
ISSN: | 0009-8981 | DOI: | 10.1016/j.cca.2007.10.006 |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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