https://scholars.lib.ntu.edu.tw/handle/123456789/475985
標題: | Angiopoietin-like protein 1 expression is related to intermuscular connective tissue and cartilage development | 作者: | DAR-MING LAI YONG-KWANG TU Hsieh Y.-H. WEN-MING HSU Lee C.-C. Cheng W.-C. FON-JOU HSIEH Li H. |
公開日期: | 2007 | 卷: | 236 | 期: | 9 | 起(迄)頁: | 2643-2652 | 來源出版物: | Developmental Dynamics | 摘要: | Angptl1, a member of the angiopoietin-related protein family, is known to regulate angiogenesis, but little is known of its potential role in other processes. To identify the expression pattern and possible role of angptl1 during embryogenesis, we used gene targeting to generate angptl1-deficient, nLacZ knockin mice. Staining for β-galactosidase from embryonic day 9.5 to 6 months of age revealed that angptl1 was initially expressed in the paraxial mesoderm. Expression then shifted to intermuscular connective tissue (fascial plane), joint capsules, and perichondrium (laryngo-trachea, ribs, and long bones), but not the muscles. The vasculature, central and peripheral nervous systems, digestive, respiratory, and other major organ systems did not show any angptl1 expression. This expression pattern suggests that angptl1 is related to development of the connective tissue and cartilage. Lack of phenotype in mutant mice may be due to a functional redundancy from other related factors. © 2007 Wiley-Liss, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-34548863154&doi=10.1002%2fdvdy.21262&partnerID=40&md5=37d0884d60af1001215e383c356bf640 https://scholars.lib.ntu.edu.tw/handle/123456789/475985 |
ISSN: | 1058-8388 | DOI: | 10.1002/dvdy.21262 |
顯示於: | 醫學系 |
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