https://scholars.lib.ntu.edu.tw/handle/123456789/476121
標題: | Regulation of BS69 expression in cancers | 作者: | Chen Y. Tsai Y.-H. SHENG-HONG TSENG |
關鍵字: | BS69; Cancer; Review; Tumorigenesis | 公開日期: | 2019 | 出版社: | International Institute of Anticancer Research | 卷: | 39 | 期: | 7 | 起(迄)頁: | 3347-3351 | 來源出版物: | Anticancer Research | 摘要: | BS69 is encoded by a gene located on chromosome 10, in a region frequently deleted in human cancers and BS69 expression is often down-regulated in human cancers. In addition, BS69 acts as a transcriptional repressor via interaction with transcriptional factors associated with tumorigenesis, such as cellular homolog of the avian myeloblastosis viral oncoprotein, v-ets erythroblastosis virus E26 oncogene homolog 2 oncoprotein, MYC-associated protein X gene-associated protein. Overexpression of BS69 can suppress proliferation of osteosarcoma, breast cancer and glioma cells in vitro; and inhibits tumor growth in xenograft models. Therefore, BS69 may act as a tumor suppressor, and may be a new target for cancer therapy. However, BS69 down-regulation has been found to be involved in cellular senescence and is associated with the reversion of the malignant phenotype of breast cancer cells. Therefore, additional studies are necessary to clarify the role of BS69 in tumor development. ? 2019 International Institute of Anticancer Research. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85068262515&doi=10.21873%2fanticanres.13477&partnerID=40&md5=97bf02b9ebe0e5ea09b626cd56eedb29 https://scholars.lib.ntu.edu.tw/handle/123456789/476121 |
ISSN: | 0250-7005 | DOI: | 10.21873/anticanres.13477 | SDG/關鍵字: | bs69 protein; tumor suppressor protein; unclassified drug; carrier protein; tumor suppressor protein; ZMYND11 protein, human; cancer inhibition; carcinogenesis; cell aging; gene expression regulation; human; malignant neoplasm; nonhuman; priority journal; protein function; revertant; Review; animal; metabolism; neoplasm; Animals; Carrier Proteins; Cellular Senescence; Humans; Neoplasms; Tumor Suppressor Proteins |
顯示於: | 醫學系 |
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