https://scholars.lib.ntu.edu.tw/handle/123456789/476130
標題: | Superparamagnetic iron oxide nanorod carriers for paclitaxel delivery in the treatment and imaging of colon cancer in mice | 作者: | Dehvari K. Chen Y. Tsai Y.-H. SHENG-HONG TSENG Lin K.-S. |
關鍵字: | Colon Cancer; MRI; Multifunctional Magnetic Nanocarrier; Paclitaxel; Superparamagnetic Iron Oxide | 公開日期: | 2016 | 出版社: | American Scientific Publishers | 卷: | 12 | 期: | 9 | 起(迄)頁: | 1734-1745 | 來源出版物: | Journal of Biomedical Nanotechnology | 摘要: | A multifunctional magnetic drug delivery system was developed and explored as an efficient and less invasive technique to improve colon cancer diagnosis and therapy in mice. In this system, superparamagnetic iron oxide nanorod cores enhanced passive targeting by bandaging a magnet adjacent to the tumor site, whereas pluronic F127 shell acted as the carrier for paclitaxel. The pluronic-conjugated superparamagnetic iron oxide cores were prepared using the hydrothermal method. It was found that the initial pluronic concentration exerted a significant effect on the distribution of the diameters and lengths of the nanorods. Despite the variation in pluronic concentrations and dimensions of iron oxide products, all the samples exhibited negligible coercivity and remanence, confirming their superparamagnetic characteristics. The pluronic F127-superparamagnetic iron oxide nanocarriers were then prepared by encapsulation of nanorods into pluronic micelles and assessed for paclitaxel loading. Results showed that paclitaxel was incorporated into the core of the micelles through hydrophobic interactions, and that elevating both paclitaxel concentration and temperature increased the loading efficiency. The therapeutic effect of paclitaxel-loaded nanocarriers was then tested in in vitro and in vivo colon cancer models. Compared to docetaxel, the paclitaxel-loaded magnetic nanocarriers significantly suppressed tumor growth and improved survival time of xenograft mice. The accumulated magnetic nanocarriers inside the tumor also served as a contrast agent and enhanced magnetic resonance imaging localization and visualization of the small tumor. Copyright ? 2016 American Scientific Publishers All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84985911915&doi=10.1166%2fjbn.2016.2283&partnerID=40&md5=83e5f2894d4590a5a6b0e2336bf32bd2 https://scholars.lib.ntu.edu.tw/handle/123456789/476130 |
ISSN: | 1550-7033 | DOI: | 10.1166/jbn.2016.2283 | SDG/關鍵字: | Diagnosis; Diseases; Hydrogels; Hydrophobicity; Iron; Magnetic resonance imaging; Magnetism; Mammals; Micelles; Nanorods; Superparamagnetism; Tumors; Coercivity and remanences; Colon cancer; Hydrophobic interactions; Magnetic drug delivery system; Magnetic nanocarrier; Magnetic nanocarriers; Paclitaxel; Superparamagnetic iron oxides; Iron oxides; docetaxel; nanocarrier; nanorod; paclitaxel; poloxamer; superparamagnetic iron oxide nanorod; unclassified drug; antineoplastic agent; drug carrier; magnetite nanoparticle; nanotube; paclitaxel; animal cell; animal experiment; animal model; Article; colon cancer; controlled study; drug delivery system; drug efficacy; drug solubility; in vitro study; in vivo study; micelle; mouse; nanoencapsulation; nanofabrication; nonhuman; nuclear magnetic resonance imaging; survival time; temperature; tumor growth; tumor localization; tumor xenograft; animal; Bagg albino mouse; chemistry; colon tumor; diagnostic imaging; pathology; theranostic nanomedicine; tumor cell line; Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Drug Carriers; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice; Mice, Inbred BALB C; Nanotubes; Paclitaxel; Theranostic Nanomedicine |
顯示於: | 醫學系 |
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