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  1. NTU Scholars
  2. 醫學院
  3. 醫學系
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/476372
Title: Advanced Paternal Age and Early Onset of Schizophrenia in Sporadic Cases: Not Confounded by Parental Polygenic Risk for Schizophrenia
Authors: Wang S.-H.
Hsiao P.-C.
Yeh L.-L.
CHIH-MIN LIU 
CHEN-CHUNG LIU 
TZUNG-JENG HWANG 
MING-HSIEN HSIEH 
YI-LING CHIEN 
YI-TING LIN 
Huang Y.-T.
Chen C.-Y.
Chandler S.D.
Faraone S.V.
Neale B.
Glatt S.J.
Tsuang M.T.
HAI-GWO HWU 
WEI J. CHEN 
Issue Date: 2019
Journal Volume: 86
Journal Issue: 1
Start page/Pages: 56-64
Source: Biological Psychiatry
Abstract: 
Background: Whether paternal age effect on schizophrenia is a causation or just an association due to confounding by selection into late parenthood is still debated. We investigated the association between paternal age and early onset of schizophrenia in offspring, controlling for both paternal and maternal predisposition to schizophrenia as empirically estimated using polygenic risk score (PRS) derived from the Psychiatric Genomics Consortium. Methods: Among 2923 sporadic schizophrenia cases selected from the Schizophrenia Trio Genomic Research in Taiwan project, 1649 had parents’ genotyping data. The relationships of paternal schizophrenia PRS to paternal age at first birth (AFB) and of maternal schizophrenia PRS to maternal AFB were examined. A logistic regression model of patients’ early onset of schizophrenia (?18 years old) on paternal age was conducted. Results: Advanced paternal age over 20 years exhibited a trend of an increasing proportion of early onset of schizophrenia (odds ratio per 10-year increase in paternal age = 1.28, p = .007) after adjusting for maternal age, sex, and age. Older paternal AFB also exhibited an increasing trend of paternal schizophrenia PRS. Additionally, a U-shaped relationship between maternal AFB and maternal schizophrenia PRS was observed. After adjusting for both paternal and maternal schizophrenia PRS, the association of paternal age with patients’ early onset of schizophrenia remained (odds ratio = 1.29, p = .04). Conclusions: The association between paternal age and early onset of schizophrenia was not confounded by parental PRS for schizophrenia, which partially captures parental genetic vulnerability to schizophrenia. Our findings support an independent role of paternal age per se in increased risk of early onset of schizophrenia in offspring. ? 2019 Society of Biological Psychiatry
URI: https://scholars.lib.ntu.edu.tw/handle/123456789/476372
DOI: 10.1016/j.biopsych.2019.01.023
SDG/Keyword: adult; Article; clinical evaluation; controlled study; disease association; disease predisposition; female; genetic analysis; genetic variability; genotype; human; major clinical study; male; maternal age; onset age; paternal age; polygenic risk score; priority journal; progeny; risk assessment; risk factor; schizophrenia; scoring system; single nucleotide polymorphism; genetic predisposition; genetics; genome-wide association study; multifactorial inheritance; onset age; paternal age; schizophrenia; Adult; Age of Onset; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Male; Multifactorial Inheritance; Paternal Age; Risk Factors; Schizophrenia
[SDGs]SDG3
Appears in Collections:醫學系

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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