https://scholars.lib.ntu.edu.tw/handle/123456789/476387
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lai C.-Y. | en_US |
dc.contributor.author | Lee S.-Y. | en_US |
dc.contributor.author | Scarr E. | en_US |
dc.contributor.author | Yu Y.-H. | en_US |
dc.contributor.author | YI-TING LIN | en_US |
dc.contributor.author | CHIH-MIN LIU | en_US |
dc.contributor.author | TZUNG-JENG HWANG | en_US |
dc.contributor.author | MING-HSIEN HSIEH | en_US |
dc.contributor.author | CHEN-CHUNG LIU | en_US |
dc.contributor.author | YI-LING CHIEN | en_US |
dc.contributor.author | Udawela M. | en_US |
dc.contributor.author | Gibbons A.S. | en_US |
dc.contributor.author | Everall I.P. | en_US |
dc.contributor.author | HAI-GWO HWU | en_US |
dc.contributor.author | Dean B. | en_US |
dc.contributor.author | WEI J. CHEN | en_US |
dc.creator | Lai C.-Y.;Lee S.-Y.;Scarr E.;Yu Y.-H.;Lin Y.-T.;Liu C.-M.;Hwang T.-J.;Ming-Hsien Hsieh;Liu C.-C.;Chien Y.-L.;Udawela M.;Gibbons A.S.;Everall I.P.;Hwu H.-G.;Dean B.;Chen W.J. | - |
dc.date.accessioned | 2020-03-17T06:22:39Z | - |
dc.date.available | 2020-03-17T06:22:39Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/476387 | - |
dc.description.abstract | Based on our previous finding of a seven-miRNA (hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572 and miR-652) signature as a potential biomarker for schizophrenia, this study aimed to examine if hospitalization could affect expressions of these miRNAs. We compared their expression levels between acute state and partial remission state in people with schizophrenia (n=48) using quantitative PCR method. Further, to examine whether the blood and brain show similar expression patterns, the expressions of two miRNAs (hsa-miR-34a and hsa-miR-548d) were examined in the postmortem brain tissue of people with schizophrenia (n=25) and controls (n=27). The expression level of the seven miRNAs did not alter after ~2 months of hospitalization with significant improvement in clinical symptoms, suggesting the miRNAs could be traits rather than state-dependent markers. The aberrant expression seen in the blood of hsa-miR-34a and hsa-miR-548d were not present in the brain samples, but this does not discount the possibility that the peripheral miRNAs could be clinically useful biomarkers for schizophrenia. Unexpectedly, we found an age-dependent increase in hsa-miR-34a expressions in human cortical (Brodmann area 46 (BA46)) but not subcortical region (caudate putamen). The correlation between hsa-miR-34a expression level in BA46 and age was much stronger in the controls than in the cases, and the corresponding correlation in the blood was only seen in the cases. The association between the miRNA dysregulations, the disease predisposition and aging warrants further investigation. Taken together, this study provides further insight on the candidate peripheral miRNAs as stable biomarkers for the diagnostics of schizophrenia. | - |
dc.relation.ispartof | Translational psychiatry | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | biological marker; microRNA; acute disease; adult; aged; blood; brain; female; human; male; metabolism; middle aged; real time polymerase chain reaction; remission; schizophrenia; young adult; Acute Disease; Adult; Aged; Biomarkers; Brain; Female; Humans; Male; MicroRNAs; Middle Aged; Real-Time Polymerase Chain Reaction; Remission Induction; Schizophrenia; Young Adult | - |
dc.title | Aberrant expression of microRNAs as biomarker for schizophrenia: from acute state to partial remission, and from peripheral blood to cortical tissue | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/tp.2015.213 | - |
dc.identifier.pmid | 26784971 | - |
dc.identifier.scopus | 2-s2.0-85017128569 | - |
dc.relation.pages | e717 | - |
dc.relation.journalvolume | 6 | - |
item.fulltext | no fulltext | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.dept | Center for Integrated Dementia Care | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Center for Artificial Intelligence and Advanced Robotics | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Psychology | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.orcid | 0000-0003-3821-4744 | - |
crisitem.author.orcid | 0000-0001-7016-8990 | - |
crisitem.author.orcid | 0000-0001-7894-9484 | - |
crisitem.author.orcid | 0000-0002-3585-7843 | - |
crisitem.author.orcid | 0000-0002-9290-110X | - |
crisitem.author.orcid | 0000-0002-3477-3015 | - |
crisitem.author.orcid | 0000-0002-2582-2807 | - |
crisitem.author.orcid | 0000-0001-5899-5870 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Science | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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