https://scholars.lib.ntu.edu.tw/handle/123456789/476415
標題: | Handedness and schizotypy in non-psychotic relatives of patients with Schizophrenia | 作者: | Tsuang H.-C. Liu C.-M. TZUNG-JENG HWANG MING-HSIEN HSIEH Faraone S.V. Tsuang M.T. Hwu H.-G. WEI J. CHEN |
公開日期: | 2011 | 卷: | 16 | 期: | 6 | 起(迄)頁: | 690-706 | 來源出版物: | Laterality | 摘要: | Existing studies have found the relationship between handedness and schizotypy to be inconsistent, and had limited generalisability since only highly homogeneous groups have been investigated. This study aimed to examine the relation between handedness and the four schizotypal factors identified from a previous confirmatory factor analysis in a population of high familial loading for schizophrenia. Study participants consisted of non-psychotic first-degree relatives (850 parents and 334 siblings) of sib-pairs who were co-affected with schizophrenia. All participants were interviewed with the Diagnostic Interview for Genetic Studies, which contains a section of the modified Structured Interview for Schizotypy, and the Annett handedness questionnaire. Both categorical and continuous indicators for handedness were examined. Non-right-handed siblings of schizophrenia patients displayed more positive schizotypal features than their right-handed counterparts when the two-way Annett's handedness classification was adopted. No association was found when handedness was treated as continuous. The relationship between handedness and schizotypy was insignificant for parents probably due to the strong social pressure against left-handedness. We concluded that categorical non-right-handedness was associated with positive schizotypy in non-psychotic siblings of schizophrenia patients. The results indicate that an atypical cerebral lateralisation underlying non-right-handedness may be also a contributing factor to positive schizotypy. ? 2011 Psychology Press. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/476415 | DOI: | 10.1080/1357650X.2010.511646 | SDG/關鍵字: | adult; article; family; female; genetic predisposition; genetics; hemispheric dominance; human; male; middle aged; pathophysiology; psychological aspect; psychology; questionnaire; schizophrenia; schizotypal personality disorder; Adult; Family; Female; Functional Laterality; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Questionnaires; Schizophrenia; Schizophrenic Psychology; Schizotypal Personality Disorder |
顯示於: | 醫學系 |
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