https://scholars.lib.ntu.edu.tw/handle/123456789/476432
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | SHU-SEN CHANG | en_US |
dc.contributor.author | Liu C.-M. | en_US |
dc.contributor.author | Lin S.-H. | en_US |
dc.contributor.author | Hwu H.-G. | en_US |
dc.contributor.author | TZUNG-JENG HWANG | en_US |
dc.contributor.author | Liu S.K. | en_US |
dc.contributor.author | MING-HSIEN HSIEH | en_US |
dc.contributor.author | Guo S.-C. | en_US |
dc.contributor.author | WEI J. CHEN | en_US |
dc.creator | Chen W.J.;Guo S.-C.;MING-HSIEN HSIEH;Liu S.K.;Hwang T.J.;Hwu H.-G.;Lin S.-H.;Liu C.-M.;Chang S.-S. | - |
dc.date.accessioned | 2020-03-17T06:22:55Z | - |
dc.date.available | 2020-03-17T06:22:55Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/476432 | - |
dc.description.abstract | We previously reported familial aggregation in flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives. However, little is known about whether this abnormal skin response is associated with genetic loading for schizophrenia. This study compared the niacin flush response in subjects from families with only one member affected with schizophrenia (simplex families) with those from families having a sib-pair with schizophrenia (multiplex families). Subjects were patients with schizophrenia and their nonpsychotic first-degree relatives from simplex families (176 probands, 260 parents, and 80 siblings) and multiplex families (311 probands, 180 parents, and 52 siblings) as well as 94 healthy controls. Niacin patches of 3 concentrations (0.001M, 0.01M, and 0.1M) were applied to forearm skin, and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. More attenuated flush response to topical niacin was shown in schizophrenia probands and their relatives from multiplex families than in their counterparts from simplex families, and the differentiation was better revealed using 0.1M concentration of niacin than 0.01M or 0.001M. For the highest concentration of 0.1M and the longest time lag of 15 minutes, a subgroup of probands (23%), parents (27%), and siblings (19%) still exhibited nonflush response. Flush response to niacin skin patch is more impaired in schizophrenia patients and their relatives from families with higher genetic loading for schizophrenia, and this finding has implications for future genetic dissection of schizophrenia. ? 2008 The Authors. | - |
dc.relation.ispartof | Schizophrenia Bulletin | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | nicotinic acid; adult; allergy; article; clinical article; controlled study; correlation coefficient; drug concentration; drug response; female; flushing; forearm; genetic heterogeneity; genetic load; human; male; priority journal; reliability; schizophrenia; sibling; skin patch; skin test; Administration, Cutaneous; Administration, Topical; Adult; Coffee; Drinking Behavior; Female; Flushing; Humans; Hypersensitivity; Male; Niacin; Schizophrenia; Smoking | - |
dc.title | Impaired flush response to niacin skin patch among schizophrenia patients and their nonpsychotic relatives: The effect of genetic loading | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1093/schbul/sbm153 | - |
dc.identifier.pmid | 18203758 | - |
dc.identifier.scopus | 2-s2.0-57749205976 | - |
dc.relation.pages | 213-221 | - |
dc.relation.journalvolume | 35 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Health Behaviors and Community Sciences | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Neurobiology and Cognitive Science Center | - |
crisitem.author.dept | Center for Integrated Dementia Care | - |
crisitem.author.dept | Psychiatry | - |
crisitem.author.dept | Psychiatry-NTUH | - |
crisitem.author.dept | Epidemiology and Preventive Medicine | - |
crisitem.author.dept | Public Health | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.orcid | 0000-0001-5012-1132 | - |
crisitem.author.orcid | 0000-0001-7894-9484 | - |
crisitem.author.orcid | 0000-0002-3585-7843 | - |
crisitem.author.orcid | 0000-0001-5899-5870 | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Public Health | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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