https://scholars.lib.ntu.edu.tw/handle/123456789/476440
標題: | Familial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relatives | 作者: | Lin S.-H. Liu C.-M. SHU-SEN CHANG Hwu H.-G. Liu S.K. TZUNG-JENG HWANG MING-HSIEN HSIEH Guo S.-C. WEI J. CHEN |
公開日期: | 2007 | 卷: | 33 | 期: | 1 | 起(迄)頁: | 174-182 | 來源出版物: | Schizophrenia Bulletin | 摘要: | Though a reduced flush response to niacin has been found in schizophrenic patients, whether it is a vulnerability indicator to schizophrenia remains little known. We aimed to examine the familial aggregation in niacin flush response among schizophrenic patients and their nonpsychotic relatives. In a sample of 153 schizophrenia probands, 217 parents, 70 siblings, and 94 normal subjects, 3 concentrations (0.001 M, 0.01 M, and 0.1 M) of niacin were applied to the forearm skin and the flush response was rated at 5, 10, and 15 minutes, respectively, with a 4-point scale. Both the heritability for continuous flush scores and the recurrence risk ratios for binary nonflush response in the nonpsychotic relatives of schizophrenic patients were estimated, and ordinal logistic regression analyses of relatives' niacin response on probands' were further conducted to adjust for potential confounders. The greatest heritabilities ranged from 47% (0.01 M at 10 minutes) to 54% (0.1 M at 5 minutes). The risk ratios of 0.01 M at 10 minutes (ranging from 2.60 for using score 1 or less to 5.06 for using score 0 as nonflush) and 5 minutes (1.66 for using score 0 as nonflush) were significantly greater than one. Multiple ordinal logistic regression analyses further revealed that the association between probands and relatives in niacin flush response remained after adjustment for potential confounders, including age, sex, allergy, tobacco smoking, and coffee drinking. These findings provide support for the potential of niacin flush response as a vulnerability indicator to schizophrenia. ? The Author 2006. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/476440 | DOI: | 10.1093/schbul/sbl038 | SDG/關鍵字: | nicotinic acid; adult; age distribution; allergy; article; coffee; controlled study; data analysis; disease predisposition; dose response; drug response; familial disease; female; flushing; forearm; genetic association; heritability; human; logistic regression analysis; major clinical study; male; priority journal; rating scale; recurrence risk; relative; sampling; schizophrenia; scoring system; sex ratio; skin; skin manifestation; smoking; Administration, Cutaneous; Adult; Aged; Dose-Response Relationship, Drug; Female; Flushing; Genetic Predisposition to Disease; Humans; Logistic Models; Male; Middle Aged; Niacin; Phenotype; Risk Assessment; Schizophrenia; Variation (Genetics) |
顯示於: | 醫學系 |
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