https://scholars.lib.ntu.edu.tw/handle/123456789/477430
標題: | Cyr61/CTGF/Nov family proteins in gastric carcinogenesis | 作者: | TSU-YAO CHENG MING-SHIANG WU KUO-TAI HUA Kuo M.-L. MING-TSAN LIN |
公開日期: | 2014 | 卷: | 20 | 期: | 7 | 起(迄)頁: | 1694-1700 | 來源出版物: | World Journal of Gastroenterology | 摘要: | Gastric cancer (GC) is the second leading cause of cancer- related death. The poor survival rate may reflect the relatively aggressive tumor biology of GC. Recently, the importance of the tumor microenvironment in carcinogenesis has emerged. In the tumor microenvironment, tumor cells and the surrounding stromal cells aberrantly secrete matricellular proteins capable of modulating carcinogenesis and regulating metastasis. The Cyr61/CTGF/Nov (CCN) proteins are a family of matricellular proteins with variable roles in many physiological and pathological processes. The evidence suggests that CCN family proteins contribute to GC carcinogenic processes. Here, we briefly review recent research on the effects of CCN family proteins in GC carcinogenesis and the development of new targeted agents in this field. ? 2014 Baishideng Publishing Group Co., Limited. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84894229065&doi=10.3748%2fwjg.v20.i7.1694&partnerID=40&md5=5297e80727de769b0c27037bc4674230 https://scholars.lib.ntu.edu.tw/handle/123456789/477430 |
ISSN: | 1007-9327 | DOI: | 10.3748/wjg.v20.i7.1694 | SDG/關鍵字: | antisense oligonucleotide; connective tissue growth factor; cyclooxygenase 2; cysteine rich protein 61; epidermal growth factor receptor; hypoxia inducible factor; immunoglobulin enhancer binding protein; mammalian target of rapamycin; monoclonal antibody; nephroblastoma overexpressed protein; phosphatidylinositol 3 kinase; plasminogen activator inhibitor 1; platelet derived growth factor; somatomedin binding protein; transcription factor AP 1; tumor necrosis factor alpha; vasculotropin; vasculotropin A; vasculotropin C; Wnt1 protein; CCN protein; connective tissue growth factor; CTGF protein, human; cysteine rich protein 61; monoclonal antibody; nephroblastoma overexpressed protein; NOV protein, human; signal peptide; article; cancer growth; cancer prognosis; carcinogenesis; human; metastasis; protein expression; signal transduction; stomach carcinoma; survival rate; tumor associated leukocyte; tumor growth; tumor microenvironment; carcinogenesis; chemistry; gene expression regulation; metabolism; mortality; protein tertiary structure; RNA interference; stomach tumor; Antibodies, Monoclonal; Carcinogenesis; CCN Intercellular Signaling Proteins; Connective Tissue Growth Factor; Cysteine-Rich Protein 61; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Metastasis; Nephroblastoma Overexpressed Protein; Protein Sorting Signals; Protein Structure, Tertiary; RNA Interference; Signal Transduction; Stomach Neoplasms |
顯示於: | 醫學系 |
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