https://scholars.lib.ntu.edu.tw/handle/123456789/477432
標題: | Bariatric surgery decreased the serum level of an endotoxin-Associated marker: Lipopolysaccharide-binding protein | 作者: | PO-JEN YANG Lee W.-J. PING-HUEI TSENG PO-HUANG LEE MING-TSAN LIN WEI-SHIUNG YANG |
公開日期: | 2014 | 出版社: | Elsevier Inc. | 卷: | 10 | 期: | 6 | 起(迄)頁: | 1182-1187 | 來源出版物: | Surgery for Obesity and Related Diseases | 摘要: | Background Recent studies have shown serum lipopolysaccharide binding protein (LBP) is associated with obesity and related metabolic disorder. Bariatric surgery can significantly reduce weight, but reports about the change of LBP after bariatric surgery are limited. We investigated LBP concentration and its associations with clinical variables.Methods We enrolled 178 obese patients receiving different bariatric surgeries and 38 normal weight individuals. Fasting blood samples were collected at baseline in all and 1 year after surgery in obese individuals. The serum LBP concentration was measured.Results The percentage of excess weight loss of mini-gastric bypass, Roux-en-Y gastric bypass, sleeve gastrectomy, and adjustable gastric band were 72.0±20.0%, 65.5±23.0%, 67.2±18.4%, and 16.1±14.3%, respectively. Serum LBP levels were higher in the obese participants than in the normal weight participants (49.9±15.7 versus 25.2±7.5 μg/mL; P<.001) at baseline and significantly decreased to 35.1±22.6 μg/mL after bariatric surgery (P<.001) in the obese group. In the bariatric participants, after multivariate analyses, preoperative LBP and the change of LBP with surgery were independently associated only with high sensitive C-reactive protein (hs-CRP) (P<.001) and the change of hs-CRP (P =.012), respectively, while none of the postoperative variables was independently associated with LBP.Conclusion LBP is associated with body mass index and hs-CRP. Bariatric surgery significantly decreased the serum level of LBP. The relationship between LBP and hs-CRP disappeared after bariatric surgery. (Surg Obes Relat Dis 2014;0:000-000.). All rights reserved. ? 2014 American Society for Metabolic and Bariatric Surgery. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84924080504&doi=10.1016%2fj.soard.2014.02.022&partnerID=40&md5=2f167948d4d40d042786f5fe291d92ef https://scholars.lib.ntu.edu.tw/handle/123456789/477432 |
ISSN: | 1550-7289 | DOI: | 10.1016/j.soard.2014.02.022 | SDG/關鍵字: | C reactive protein; lipopolysaccharide binding protein; acute phase protein; biological marker; C reactive protein; carrier protein; lipopolysaccharide-binding protein; membrane protein; adult; Article; bariatric surgery; blood sampling; controlled study; female; gastric band; human; major clinical study; male; obesity; priority journal; protein blood level; Roux Y anastomosis; sleeve gastrectomy; stomach bypass; weight reduction; bariatric surgery; blood; body mass; cohort analysis; comparative study; follow up; gastrectomy; gastroplasty; metabolism; middle aged; multivariate analysis; Obesity, Morbid; postoperative care; preoperative care; procedures; prospective study; statistical model; treatment outcome; Acute-Phase Proteins; Adult; Bariatric Surgery; Biological Markers; Body Mass Index; C-Reactive Protein; Carrier Proteins; Cohort Studies; Female; Follow-Up Studies; Gastrectomy; Gastric Bypass; Gastroplasty; Humans; Linear Models; Male; Membrane Glycoproteins; Middle Aged; Multivariate Analysis; Obesity, Morbid; Postoperative Care; Preoperative Care; Prospective Studies; Treatment Outcome; Weight Loss |
顯示於: | 醫學系 |
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