https://scholars.lib.ntu.edu.tw/handle/123456789/477446
Title: | Parenteral glutamine supplement has synergic effects in minimally invasive surgery of subtotal gastrectomy patients | Authors: | CHIEN-CHIA CHEN Chang T.-C. Wang M.-Y. MING-HSUN WU MING-TSAN LIN |
Issue Date: | 2012 | Journal Volume: | 59 | Journal Issue: | 118 | Start page/Pages: | 1776-1779 | Source: | Hepato-Gastroenterology | Abstract: | Background/Aims: Exogenous glutamine supplement is known to improve morbidity and mortality of critically-ill patients. This study was conducted to elucidate the role of glutamine in minimally invasive surgery. Methodology: We retrospectively reviewed subtotal gastrectomy patients in National Taiwan University Hospital from Dec 2005 to Dec 2008. The patients were divided into three groups. Group 1 underwent subtotal gastrectomy by laparotomy without glutamine supplement, group 2 underwent subtotal gastrectomy by laparotomy with glutamine supplement and group 3 underwent gasless laparoscopy-assisted subtotal gastrectomy with parenteral glutamine supplement. Results: There were 155 patients in total; 85 patients in group 1, 17 in group 2 and 53 in group 3. The mean flatus days after operation are 3.6, 3.1 and 2.8 for groups 1, 2 and 3, respectively (p=0.001). Oral intake after operation was commenced after 6.7, 5.0 and 4.7 days (p=0.006). The body temperature had borderline differences between groups 3 and 1. There were significant differences in postoperative systemic responses including heart rates (p<0.001) and tenderness (p=0.011) 5 days after operation for group 3 vs. group 1. Minimally invasive surgery was a negative factor for postoperative body temperature change. Glutamine was a significant factor for postoperative heart rate change and reduction of tenderness. Conclusions: Glutamine supplement may have synergic effects of rapid recovery in minimal invasive surgery for subtotal gastrectomy patients by minimizing the postoperative systemic response and accelerating recovery. ? H.G.E. Update Medical Publishing S.A. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867725866&doi=10.5754%2fhge10270&partnerID=40&md5=e2168bd51c4d7a26d1a01f860b44cd02 https://scholars.lib.ntu.edu.tw/handle/123456789/477446 |
ISSN: | 0172-6390 | DOI: | 10.5754/hge10270 | SDG/Keyword: | glutamine; morphine; adult; article; bleeding; body temperature; cancer staging; controlled study; diet supplementation; female; flatulence; heart rate; human; laparotomy; major clinical study; male; minimally invasive surgery; operation duration; parenteral nutrition; patient monitoring; postoperative period; priority journal; stomach cancer; subtotal gastrectomy; Aged; Body Temperature Regulation; Dietary Supplements; Female; Gastrectomy; Glutamine; Heart Rate; Humans; Laparoscopy; Linear Models; Male; Middle Aged; Parenteral Nutrition; Postoperative Complications; Recovery of Function; Retrospective Studies; Taiwan; Time Factors; Treatment Outcome |
Appears in Collections: | 醫學系 |
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