https://scholars.lib.ntu.edu.tw/handle/123456789/477452
Title: | Serum vascular endothelial growth factor-D levels correlate with cervical lymph node metastases in papillary thyroid carcinoma | Authors: | Lai C.-W. KUEN-YUAN CHEN Hung C.-S. Kuo S.-W. Chang Y.-J. MING-TSAN LIN Chang K.-C. MING-HSUN WU |
Issue Date: | 2011 | Journal Volume: | 29 | Journal Issue: | 2-3 | Start page/Pages: | 57-62 | Source: | Growth Factors | Abstract: | The aim of this multicenter study was to evaluate the clinical relevance of serum vascular endothelial growth factor-D (VEGF-D) in papillary thyroid carcinoma (PTC). This prospective study consisted of 74 patients with primary PTC and 15 patients with benign thyroid nodules treated from 2008 to 2009. VEGF-D concentration was compared with patient clinicopathologic features and lymph node metastases. There was no significant difference in mean serum VEGF-D levels between the PTC and benign thyroid nodule groups. Within the PTC group, serum VEGF-D levels were significantly higher in patients with lymph node metastases than in patients without metastases (241.92 vs. 213.89 pg/ml, respectively; P = 0.035). Receiver operating characteristic curve analysis revealed that preoperative serum VEGF-D levels were predictive of lymph node metastases in the patients >45 years. Serum VEGF-D level that was correlated with the presence of cervical lymph node metastases in PTC patients might be a useful prognostic indicator. ? 2011 Informa UK, Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79955846725&doi=10.3109%2f08977194.2011.557373&partnerID=40&md5=2e9314f849f3e54b6d2c9f507262abcb https://scholars.lib.ntu.edu.tw/handle/123456789/477452 |
ISSN: | 0897-7194 | DOI: | 10.3109/08977194.2011.557373 | SDG/Keyword: | vasculotropin D; adult; article; cervical lymph node; comparative study; disease marker; female; human; lymph node metastasis; major clinical study; male; priority journal; prognosis; protein blood level; protein function; receiver operating characteristic; thyroid nodule; thyroid papillary carcinoma; Adult; Carcinoma, Papillary; Female; Humans; Lymphatic Metastasis; Male; Middle Aged; ROC Curve; Thyroid Neoplasms; Vascular Endothelial Growth Factor D |
Appears in Collections: | 醫學系 |
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