https://scholars.lib.ntu.edu.tw/handle/123456789/477506
標題: | Glutamine-supplemented total parenteral nutrition attenuates plasma interleukin-6 in surgical patients with lower disease severity | 作者: | MING-TSAN LIN Kung S.-P. Yeh S.-L. Liaw K.-Y. Wang M.-Y. Kuo M.-L. PO-HUANG LEE Chen W.-J. |
公開日期: | 2005 | 出版社: | WJG Press | 卷: | 11 | 期: | 39 | 起(迄)頁: | 6197-6201 | 來源出版物: | World Journal of Gastroenterology | 摘要: | Aim: To evaluate whether the effect of Gln dipeptide-enriched total parenteral nutrition (TPN) on postoperative cytokine alteration depended on the disease severity of surgical patients. Methods: Forty-eight patients with major abdominal surgery were allocated to two groups to receive isonitrogenous (0.228 g nitrogen/kg per d) and isocaloric (30 kcal/kg per d) TPN for 6 d. Control group (Conv) using conventional TPN solution received 1.5 g amino acids/kg per day, whereas the test group received 0.972 g amino acids/kg per day and 0.417 g L-alanyl-L-glutamine (Ala-Gln)/kg per day. Blood samples were collected on d 1 and d 6 postoperatively for plasma interleukin (IL)-2, IL-6, IL-8, and interferon (IFN)-γ analysis. Results: Plasma IL-2 and IFN-γ were not detectable. IL-6 concentrations were significantly lower on the 6th postoperative day in the Ala-Gln group than those in the Conv group in patients with APACHE II?6, whereas no difference was noted in patients with APACHE II>6. There was no difference in IL-8 levels between the two groups. No difference in cumulative nitrogen balance was observed on d 2-5 after the operation between the two groups (Ala-Gln -3.2±1.6 g vs Conv -6.5±2.7 g). A significant inverse correlation was noted between plasma IL-6 levels and cumulative nitrogen balance postoperatively in the Ala-Gln group, whereas no such correlation was observed in the Conv group. Conclusion: TPN supplemented with Gin dipeptide had no effect on plasma IL-8 levels after surgery. However, Gln supplementation had a beneficial effect on decreasing systemic IL-6 production after surgery in patients with low admission illness severity, and lower plasma IL-6 may improve nitrogen balance in patients with abdominal surgery when Gln was administered. ? 2005 The WJG Press and Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-30644469266&doi=10.3748%2fwjg.v11.i39.6197&partnerID=40&md5=c470d0bb779bcb85f97c0531917848a5 https://scholars.lib.ntu.edu.tw/handle/123456789/477506 |
ISSN: | 1007-9327 | DOI: | 10.3748/wjg.v11.i39.6197 | SDG/關鍵字: | alanylglutamine; amino acid; gamma interferon; interleukin 2; interleukin 6; interleukin 8; nitrogen; abdominal surgery; adult; aged; article; blood sampling; caloric intake; clinical article; clinical trial; colon cancer; controlled clinical trial; controlled study; correlation analysis; cytokine production; disease severity; double blind procedure; duodenum cancer; enzyme linked immunosorbent assay; female; hospitalization; human; liver cell carcinoma; male; multicenter study; nitrogen balance; nutritional support; pancreas cancer; parallel design; postoperative care; postoperative complication; postoperative period; protein blood level; randomized controlled trial; rectum cancer; side effect; stomach cancer; total parenteral nutrition |
顯示於: | 醫學系 |
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