https://scholars.lib.ntu.edu.tw/handle/123456789/477675
標題: | Seroprevalence of Helicobacter pylori in patients with surgical peptic ulcer | 作者: | Lee W.-J. Wu M.-S. CHIUNG-NIEN CHEN Yuan R.-H. Lin J.-T. KING-JEN CHANG |
公開日期: | 1997 | 出版社: | American Medical Association | 卷: | 132 | 期: | 4 | 起(迄)頁: | 430-433 | 來源出版物: | Archives of Surgery | 摘要: | Background: Helicobacter pylori is known as a major cofactor in ulcerogenesis. However, the role of H pylori in surgical patients with peptic ulcer and its possible influence on surgical treatment is unclear.Objectives: To determine the prevalence of H pylori infection in surgical patients with complicated peptic ulcer diseases and analyze its clinical significance. Design: A prospective, controlled study. Setting: University-affiliated hospital and tertiary care center. Subjects: Two study groups: surgical group (n=66), ie, patients who received surgical treatment for their peptic ulcer disease), and control group (n=377) comprising 3 subgroups: normal volunteers (NV subgroup, n=136) and patients who required only medical treatment for duodenal ulcer (DU subgroup, n= 119) or gastric ulcer (GU sub-group, n=122) from January 1, 1994 to June 30, 1995. Methods: Preoperative or overnight fasting serum samples were collected, and H pylori state was assessed by serum anti-H pylori IgG. Results: Seropositivity was similar between the surgical group (60.6%) and NV control subgroup (58.8%), but it was highest in the DU control subgroup (87.4%) (P<.001 compared with NV control subgroup), followed by GU control subgroup (76.2%) (P<.01 compared NV). The patients with surgical peptic ulcer who had both seropositive and seronegative results for H pylori were similar for sex, age, social status, ulcer history, associated major medical problems, use of nonsteroid anti-inflammatory drugs, ulcer location, type of surgery, and ulceration recurrence rate. Although patients who underwent elective surgery had a higher seroprevalence rate (88.9%) than those requiring emergency surgery (56.4%) and patients who were seronegative for H pylori seemed to be associated with a higher major morbidity, these results were not statistically significant. Conclusion: No significant association of H pylori infection and peptic ulcer was noted between patients who required surgical treatment compared with those who required only medical treatment; H pylori played only a limited role in the cause of disease in surgical patients, perhaps only in the cases complicated with stenosis or intractable ulcers. This suggests that presently adequate acid reduction procedure will still be the main objective of surgical treatment and prevention of the ulcer recurrence. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0030981974&doi=10.1001%2farchsurg.1997.01430280104017&partnerID=40&md5=af4b12fda1cdf8b0dd9051e8002c63ea https://scholars.lib.ntu.edu.tw/handle/123456789/477675 |
ISSN: | 0004-0010 | DOI: | 10.1001/archsurg.1997.01430280104017 | SDG/關鍵字: | adult; article; elective surgery; female; Helicobacter pylori; histopathology; human; major clinical study; male; peptic ulcer; priority journal; seroprevalence; stenosis; ulcer healing; ulcerogenesis; vagotomy |
顯示於: | 醫學系 |
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