https://scholars.lib.ntu.edu.tw/handle/123456789/477804
標題: | Increased risk for invasive breast cancer associated with hormonal therapy: A nation-wide random sample of 65,723 women followed from 1997 to 2008 | 作者: | Lai J.-N. Wu C.-T. PAU-CHUNG CHEN CHIUN-SHENG HUANG SONG-NAN CHOW Wang J.-D. |
公開日期: | 2011 | 卷: | 6 | 期: | 10 | 起(迄)頁: | e25183 | 來源出版物: | PLoS ONE | 摘要: | Background: Hormonal therapy (HT) either estrogen alone (E-alone) or estrogen plus progesterone (E+P) appears to increase the risk for breast cancer in Western countries. However, limited information is available on the association between HT and breast cancer in Asian women characterized mainly by dietary phytoestrogens intake and low prevalence of contraceptive pills prescription. Methodology: A total of 65,723 women (20-79 years of age) without cancer or the use of Chinese herbal products were recruited from a nation-wide one-million representative sample of the National Health Insurance of Taiwan and followed from 1997 to 2008. Seven hundred and eighty incidents of invasive breast cancer were diagnosed. Using a reference group that comprised 40,052 women who had never received a hormone prescription, Cox proportional hazard models were constructed to determine the hazard ratios for receiving different types of HT and the occurrence of breast cancer. Conclusions: 5,156 (20%) women ever used E+P, 2,798 (10.8%) ever used E-alone, and 17,717 (69%) ever used other preparation types. The Cox model revealed adjusted hazard ratios (HRs) of 2.05 (95% CI 1.37-3.07) for current users of E-alone and 8.65 (95% CI 5.45-13.70) for current users of E+P. Using women who had ceased to take hormonal medication for 6 years or more as the reference group, the adjusted HRs were significantly elevated and greater than current users and women who had discontinued hormonal medication for less than 6 years. Current users of either E-alone or E+P have an increased risk for invasive breast cancer in Taiwan, and precautions should be taken when such agents are prescribed. ? 2011 Lai et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-80053614843&doi=10.1371%2fjournal.pone.0025183&partnerID=40&md5=0c9d4e4b78221dd2347b2c3827413082 https://scholars.lib.ntu.edu.tw/handle/123456789/477804 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0025183 | SDG/關鍵字: | conjugated estrogen; medroxyprogesterone; adult; age distribution; aged; article; breast cancer; cancer incidence; cancer invasion; cancer risk; combination chemotherapy; controlled study; disease association; female; follow up; hormonal therapy; human; major clinical study; monotherapy; prescription; risk assessment; risk factor; breast tumor; cohort analysis; hormone substitution; middle aged; multivariate analysis; pathology; proportional hazards model; retrospective study; risk; Taiwan; Adult; Aged; Breast Neoplasms; Cohort Studies; Female; Hormone Replacement Therapy; Humans; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Proportional Hazards Models; Retrospective Studies; Risk; Taiwan; Young Adult |
顯示於: | 醫學系 |
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