https://scholars.lib.ntu.edu.tw/handle/123456789/477812
標題: | Reduction of breast density following tamoxifen treatment evaluated by 3-D MRI: Preliminary study | 作者: | Chen J.-H. YEUN-CHUNG CHANG Chang D. Wang Y.-T. Nie K. Chang R.-F. Nalcioglu O. CHIUN-SHENG HUANG Su M.-Y. |
公開日期: | 2011 | 卷: | 29 | 期: | 1 | 起(迄)頁: | 91-98 | 來源出版物: | Magnetic Resonance Imaging | 摘要: | This study analyzed the change in breast density in women receiving tamoxifen treatment using 3-D MRI. Sixteen women were studied. Each woman received breast MRI before and after tamoxifen. The breast and the fibroglandular tissue were segmented using a computer-assisted algorithm, based on T1-weighted images. The fibroglandular tissue volume (FV) and breast volume (BV) were measured and the ratio was calculated as the percent breast density (%BD). The changes in breast volume (ΔBV), fibroglandular tissue volume (ΔFV) and percent density (Δ%BD) between two MRI studies were analyzed and correlated with treatment duration and baseline breast density. The ΔFV showed a reduction in all 16 women. The Δ%BD showed a mean reduction of 5.8%. The reduction of FV was significantly correlated with baseline FV (P<001) and treatment duration (P=03). The percentage change in FV was correlated with duration (P=049). The reduction in %BD was positively correlated with baseline %BD (P=02). Women with higher baseline %BD showed more reduction of %BD. Three-dimensional MRI may be useful for the measurement of the small changes of ΔFV and Δ%BD after tamoxifen. These changes can potentially be used to correlate with the future reduction of cancer risk. ? 2011 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-78649930824&doi=10.1016%2fj.mri.2010.07.009&partnerID=40&md5=83169cc9a574584b2a45ff13da67c4fc https://scholars.lib.ntu.edu.tw/handle/123456789/477812 |
ISSN: | 0730-725X | DOI: | 10.1016/j.mri.2010.07.009 | SDG/關鍵字: | tamoxifen; adult; analytical parameters; article; breast cancer; breast density; breast surgery; breast volume; cancer risk; clinical article; computer analysis; controlled study; drug response; female; fibroglandular tissue volume; human; image analysis; image processing; nuclear magnetic resonance imaging; priority journal; retrospective study; risk reduction; three dimensional imaging; treatment duration; Adult; Antineoplastic Agents, Hormonal; Breast; Breast Neoplasms; Female; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Middle Aged; Pilot Projects; Prognosis; Tamoxifen; Treatment Outcome |
顯示於: | 醫學系 |
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