|Title:||Basics and applications of tumor-derived extracellular vesicles||Authors:||Tai Y.-L.
|Issue Date:||2019||Publisher:||BioMed Central Ltd.||Journal Volume:||26||Journal Issue:||1||Start page/Pages:||35||Source:||Journal of Biomedical Science||Abstract:||
Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering the tumor microenvironment and thereby modulating cancer developments that may contribute to drug resistance and cancer recurrence. Moreover, the molecular and functional characteristics of cancer through its development and posttreatment evolve over time. Tumor-derived EVs are profoundly involved in this process and can, therefore, provide valuable real-time information to reflect dynamic changes occurring within the body. Because they bear unique molecular profiles or signatures, tumor-derived EVs have been highlighted as valuable diagnostic and predictive biomarkers as well as novel therapeutic targets. In addition, the use of an advanced EV-based drug delivery system for cancer therapeutics has recently been emphasized in both basic and clinical studies. In this review, we highlight comprehensive aspects of tumor-derived EVs in oncogenic processes and their potential clinical applications. ? 2019 The Author(s).
|ISSN:||1021-7770||DOI:||10.1186/s12929-019-0533-x||SDG/Keyword:||integrin; messenger RNA; microRNA; tumor marker; 3' untranslated region; binding affinity; cancer diagnosis; cancer growth; cancer therapy; carcinogenesis; cell isolation; cell transport; clinical feature; drug delivery system; epithelial mesenchymal transition; exosome; gene expression; genetic variability; homeostasis; human; immunotherapy; intracellular signaling; practice guideline; priority journal; protein function; Review; tumor microenvironment; cell communication; exosome; neoplasm; oncogene; physiology; procedures; tumor microenvironment; Cell Communication; Drug Delivery Systems; Extracellular Vesicles; Humans; Neoplasms; Oncogenes; Tumor Microenvironment
|Appears in Collections:||醫學系|
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