https://scholars.lib.ntu.edu.tw/handle/123456789/478365
標題: | Basics and applications of tumor-derived extracellular vesicles | 作者: | Tai Y.-L. Chu P.-Y. Lee B.-H. Chen K.-C. Yang C.-Y. WEN-HUNG KUO TANG-LONG SHEN |
公開日期: | 2019 | 出版社: | BioMed Central Ltd. | 卷: | 26 | 期: | 1 | 起(迄)頁: | 35 | 來源出版物: | Journal of Biomedical Science | 摘要: | Extracellular vesicle (EV)-mediated intercellular communication acts as a critical culprit in cancer development. The selective packaging of oncogenic molecules renders tumor-derived EVs capable of altering the tumor microenvironment and thereby modulating cancer developments that may contribute to drug resistance and cancer recurrence. Moreover, the molecular and functional characteristics of cancer through its development and posttreatment evolve over time. Tumor-derived EVs are profoundly involved in this process and can, therefore, provide valuable real-time information to reflect dynamic changes occurring within the body. Because they bear unique molecular profiles or signatures, tumor-derived EVs have been highlighted as valuable diagnostic and predictive biomarkers as well as novel therapeutic targets. In addition, the use of an advanced EV-based drug delivery system for cancer therapeutics has recently been emphasized in both basic and clinical studies. In this review, we highlight comprehensive aspects of tumor-derived EVs in oncogenic processes and their potential clinical applications. ? 2019 The Author(s). |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065637762&doi=10.1186%2fs12929-019-0533-x&partnerID=40&md5=c17e5147f818df8af7bade436e0c1fc4 https://scholars.lib.ntu.edu.tw/handle/123456789/478365 |
ISSN: | 1021-7770 | DOI: | 10.1186/s12929-019-0533-x | SDG/關鍵字: | integrin; messenger RNA; microRNA; tumor marker; 3' untranslated region; binding affinity; cancer diagnosis; cancer growth; cancer therapy; carcinogenesis; cell isolation; cell transport; clinical feature; drug delivery system; epithelial mesenchymal transition; exosome; gene expression; genetic variability; homeostasis; human; immunotherapy; intracellular signaling; practice guideline; priority journal; protein function; Review; tumor microenvironment; cell communication; exosome; neoplasm; oncogene; physiology; procedures; tumor microenvironment; Cell Communication; Drug Delivery Systems; Extracellular Vesicles; Humans; Neoplasms; Oncogenes; Tumor Microenvironment |
顯示於: | 醫學系 |
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