https://scholars.lib.ntu.edu.tw/handle/123456789/478435
標題: | Cumulative survival in early-onset unilateral and bilateral breast cancer: An analysis of 1907 Taiwanese women | 作者: | WEN-HUNG KUO Yen A.M.-F. PO-HUANG LEE Chen K.-M. JANN-YUAN WANG KING-JEN CHANG Chen, Tony Hsiu Hsi Tsau H.-S. |
公開日期: | 2009 | 卷: | 100 | 期: | 4 | 起(迄)頁: | 563-570 | 來源出版物: | British Journal of Cancer | 摘要: | As the epidemiological pattern of breast cancer in modernising Asian countries differs greatly from that in Western countries, it is worthwhile to investigate the long-term prognoses of unilateral and bilateral breast cancer in these nations. A retrospective cohort study composed of 1907 Taiwanese women was conducted to follow 1863 unilateral and 44 bilateral cases of breast cancer. Time-dependent Cox regression was used to assess the risk of breast cancer death by considering the time course of unilateral and bilateral tumour development. The 15-year survival rates were 68.37, 62.63, and 26.42% for unilateral, synchronous bilateral, and metachronous bilateral breast cancer, respectively. Differences among types were most apparent after 5 years of follow-up. After adjusting for significant prognostic factors, the risk of death for overall bilateral breast cancer was 2.50-fold greater (95% CI, 1.43-4.37) compared to unilateral breast cancer. The corresponding figures were 1.12-fold (95% CI, 0.42-3.02) and 6.11-fold (95% CI, 3.14-11.89) for synchronous and metachronous bilateral breast cancer, respectively. Taiwanese women, who are frequently diagnosed with breast cancer before 50 years of age, showed poorer survival for metachronous bilateral than for synchronous bilateral or unilateral breast cancer. Survival was markedly poorer compared to recent data from Sweden. ? 2009 Cancer Research UK. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-60349091874&doi=10.1038%2fsj.bjc.6604898&partnerID=40&md5=95c63e738915b458825ae102c85683ef https://scholars.lib.ntu.edu.tw/handle/123456789/478435 |
ISSN: | 0007-0920 | DOI: | 10.1038/sj.bjc.6604898 | SDG/關鍵字: | adult; article; bilateral cancer; breast cancer; cancer mortality; cancer risk; cancer staging; cancer survival; cohort analysis; comparative study; controlled study; female; follow up; human; major clinical study; priority journal; prognosis; proportional hazards model; retrospective study; risk factor; survival rate; Taiwan; Adult; Age of Onset; Breast Neoplasms; Cohort Studies; Female; Humans; Middle Aged; Prognosis; Retrospective Studies; Survival Rate; Taiwan |
顯示於: | 醫學系 |
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