https://scholars.lib.ntu.edu.tw/handle/123456789/478689
標題: | Risk for subsequent infection and mortality after hospitalization among patients with multidrug-resistant gram-negative bacteria colonization or infection | 作者: | WEN-PIN TSENG YEE-CHUN CHEN Shang-Yu Chen SHEY-YING CHEN SHAN-CHWEN CHANG |
公開日期: | 2018 | 卷: | 7 | 期: | 1 | 起(迄)頁: | 93 | 來源出版物: | Antimicrobial Resistance and Infection Control | 摘要: | Background: Risks for subsequent multidrug-resistant gram-negative bacteria (MDRGNB) infection and long-term outcome after hospitalization among patients with MDRGNB colonization remain unknown. Methods: This observational study enrolled 817 patients who were hospitalized in the study hospital in 2009. We defined MDRGNB as a GNB resistant to at least three different antimicrobial classes. Patients were classified into MDRGNB culture-positive (MDRGNB-CP; 125 patients) and culture-negative (MDRGNB-CN; 692 patients) groups based on the presence or absence of any MDRGNB identified from either active surveillance or clinical cultures during index hospitalization. Subsequent MDRGNB infection and mortality within 12 months after index hospitalization were recorded. We determined the frequency and risk factors for subsequent MDRGNB infection and mortality associated with previous MDRGNB culture status. Results: In total, 129 patients had at least one subsequent MDRGNB infection (MDRGNB-CP, 48.0%; MDRGNB-CN, 10.0%), and 148 patients died (MDRGNB-CP, 31.2%; MDRGNB-CN, 15.9%) during the follow-up period. MDR Escherichia coli and Acinetobacter baumannii were the predominant colonization microorganisms; patients with Proteus mirabilis and Pseudomonas aeruginosa had the highest hazard risk for developing subsequent infection. After controlling for other confounders, MDRGNB-CP during hospitalization independently predicted subsequent MDRGNB infection (hazard ratio [HR], 5.35; 95% confidence interval [CI], 3.72-7.71), all-cause mortality (HR, 2.42; 95% CI, 1.67-3.50), and subsequent MDRGNB infection-associated mortality (HR, 4.88; 95% CI, 2.79-8.52) after hospitalization. Conclusions: Harboring MDRGNB significantly increases patients' risk for subsequent MDRGNB infection and mortality after hospitalization, justifying the urgent need for developing effective strategies to prevent and eradicate MDRGNB colonization. ? 2018 The Author(s). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/478689 | ISSN: | 2047-2994 | DOI: | 10.1186/s13756-018-0388-z | SDG/關鍵字: | aminoglycoside antibiotic agent; cefixime; ceftazidime; ciprofloxacin; imipenem; levofloxacin; meropenem; piperacillin plus tazobactam; sultamicillin; timentin; antiinfective agent; abdominal infection; Acinetobacter baumannii; adult; aged; antibiotic resistance; Article; bacterial colonization; bacterium culture; bacterium isolation; bloodstream infection; controlled study; disease association; Escherichia coli; female; Gram negative infection; hospitalization; human; infection risk; Klebsiella pneumoniae; length of stay; major clinical study; male; mortality risk; multidrug resistance; nonhuman; observational study; prevalence; priority journal; Proteus mirabilis; Pseudomonas aeruginosa; respiratory tract infection; retrospective study; urinary tract infection; classification; cross infection; drug effect; genetics; Gram negative bacterium; Gram negative infection; growth, development and aging; hospitalization; microbiology; middle aged; mortality; prospective study; statistics and numerical data; teaching hospital; very elderly; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cross Infection; Drug Resistance, Multiple, Bacterial; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Hospitalization; Hospitals, Teaching; Humans; Male; Middle Aged; Prospective Studies; Retrospective Studies |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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