https://scholars.lib.ntu.edu.tw/handle/123456789/478751
標題: | Detection of severe acute respiratory syndrome coronavirus RNA in plasma during the course of infection | 作者: | Wang W.-K. CHI-TAI FANG Chen H.-L. Yang C.-F. YEE-CHUN CHEN Chen M.-L. SHEY-YING CHEN Yang J.-Y. Lin J.-H. PAN-CHYR YANG SHAN-CHWEN CHANG |
公開日期: | 2005 | 卷: | 43 | 期: | 2 | 起(迄)頁: | 962-965 | 來源出版物: | Journal of Clinical Microbiology | 摘要: | We examined severe acute respiratory syndrome-associated coronavirus (SARS-CoV) RNA in plasma of 32 patients (probable SARS cases) by a quantitative real-time reverse transcription-PCR assay and reported that the highest detection rate, 75%, was found between day 5 and day 7 of illness, followed by rates of 64, 50, and 38% found between day 8 and day 11, day 2 and day 4, and day 12 and day 16, respectively. Analysis of sequential SARS-CoV load in plasma from sis cases revealed different patterns of viremia, with the peak between day 4 and day 8. Our findings of the high detection rate of SARS-CoV RNA in plasma before day 11, together with the relative convenience of collecting and handling plasma, suggest that plasma can be used for early diagnosis of SARS. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/478751 | ISSN: | 0095-1137 | DOI: | 10.1128/JCM.43.2.962-965.2005 | SDG/關鍵字: | virus RNA; adult; aged; article; chronology; clinical article; early diagnosis; female; human; male; plasma; priority journal; real time polymerase chain reaction; RNA isolation; severe acute respiratory syndrome; viremia; virus identification; virus load; Adult; Aged; Female; Humans; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; SARS Virus; Severe Acute Respiratory Syndrome; Taiwan; Coronavirus; RNA viruses; SARS CoV |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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