https://scholars.lib.ntu.edu.tw/handle/123456789/479300
標題: | Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression | 作者: | ANG YUAN Hsiao Y.-J. Chen H.-Y. HUEI-WEN CHEN CHAO-CHI HO Chen Y.-Y. Liu Y.-C. Hong T.-H. SUNG-LIANG YU Chen J.J.W. PAN-CHYR YANG |
公開日期: | 2015 | 卷: | 5 | 起(迄)頁: | 14273 | 來源出版物: | Scientific Reports | 摘要: | Macrophages in a tumor microenvironment have been characterized as M1-And M2-polarized subtypes. Here, we discovered the different macrophagesa €? impacts on lung cancer cell A549. The M2a/M2c subtypes promoted A549 invasion and xenograft tumor growth. The M1 subtype suppressed angiogenesis. M1 enhanced the sensitivity of A549 to cisplatin and decreased the tube formation activity and cell viability of A549 cells by inducing apoptosis and senescence. Different macrophage subtypes regulated genes involved in the immune response, cytoskeletal remodeling, coagulation, cell adhesion, and apoptosis pathways in A549 cells, which was a pattern that correlated with the altered behaviors of the A549 cells. Furthermore, we found that the identified M1/M2 gene signatures were significantly correlated with the extended overall survival of lung cancer patients. These results suggest that M1/M2 gene expression signature may be used as a prognostic indicator for lung cancer patients, and M1/M2 polarization may be a target of investigation of immune-modulating therapies for lung cancer in the future. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/479300 | ISSN: | 2045-2322 | DOI: | 10.1038/srep14273 | SDG/關鍵字: | antineoplastic agent; biological marker; animal; cell proliferation; cell survival; cluster analysis; drug effects; drug resistance; female; gene expression profiling; genetics; human; immunology; immunophenotyping; Kaplan Meier method; lung tumor; macrophage; male; metabolism; mortality; mouse; neovascularization (pathology); pathology; phenotype; prognosis; proportional hazards model; tumor cell line; Animals; Antineoplastic Agents; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cluster Analysis; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Immunophenotyping; Kaplan-Meier Estimate; Lung Neoplasms; Macrophages; Male; Mice; Neovascularization, Pathologic; Phenotype; Prognosis; Proportional Hazards Models |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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