|Title:||PET/MRI for evaluating subclinical inflammation of ulcerative colitis||Authors:||Shih I.-L.
|Issue Date:||2018||Journal Volume:||47||Journal Issue:||3||Start page/Pages:||737-745||Source:||Journal of Magnetic Resonance Imaging||Abstract:||
Purpose: To explore the utility of integrated positron emission tomography (PET) / magnetic resonance imaging (MRI) for evaluating subclinical inflammation in patients with ulcerative colitis (UC). Materials and Methods: This prospective study was approved by the Institutional Review Board and informed consent was obtained. Between November 2015 and April 2016, 19 consecutive patients with UC in clinical remission were enrolled. These patients underwent 18F-fluorodeoxyglucose PET/MRI (3T) and colonoscopy. Serum high-sensitivity C-reactive protein (hs-CRP) and fecal calprotectin (FC) levels were also obtained. The findings of colonoscopy were graded using the Mayo endoscopic subscore. Quantitative (minimum apparent diffusion coefficient [ADC min ] and maximum standardized uptake value [SUV max ]), semiquantitative, and qualitative parameters of PET/MRI were evaluated and correlated with colonoscopic findings. Results: In per-segment analysis, ADC min was significantly lower and SUV max and ratio of SUV max to ADC min were significantly higher in the colonic segments with active inflammation (Mayo endoscopic subscore ?2) (P < 0.05). Qualitative MRI score, PET activity grade, and PET/MRI score were also significantly higher in the colonic segments with active inflammation (P < 0.05). Among these parameters, the ratio of SUV max to ADC min exhibited the highest area under the receiver operating characteristic curve (AUC) (0.763). In per-patient analysis, the AUC of PET activity grade was 0.778, higher than those of hs-CRP (0.589) and FC (0.722). Using a combined index of FC and PET, an even higher AUC (0.867) was achieved. Conclusion: PET/MRI is a potentially useful tool in identifying subclinical inflammation in patients with UC. Level of Evidence: 1. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2018;47:737–745. ? 2017 International Society for Magnetic Resonance in Medicine
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/479409||ISSN:||1053-1807||DOI:||10.1002/jmri.25795||metadata.dc.subject.other:||C reactive protein; calgranulin; fluorodeoxyglucose f 18; radiopharmaceutical agent; adult; aged; area under the curve; Article; clinical article; colonoscopy; digestive system disease assessment; feces level; female; human; inflammation; male; Mayo endoscopic subscore; nuclear magnetic resonance imaging; positron emission tomography; priority journal; prospective study; protein blood level; qualitative analysis; quantitative analysis; receiver operating characteristic; remission; scoring system; subclinical inflammation; ulcerative colitis; colon; complication; diagnostic imaging; inflammation; middle aged; multimodal imaging; nuclear magnetic resonance imaging; pilot study; positron emission tomography; procedures; reproducibility; severity of illness index; ulcerative colitis; young adult; Adult; Aged; Colitis, Ulcerative; Colon; Female; Fluorodeoxyglucose F18; Humans; Inflammation; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Pilot Projects; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Reproducibility of Results; Severity of Illness Index; Young Adult
|Appears in Collections:||醫學院附設醫院 (臺大醫院)|
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