https://scholars.lib.ntu.edu.tw/handle/123456789/479449
標題: | Metabolic syndrome and abdominal fat are associated with inflammation, but not with clinical outcomes, in peritoneal dialysis patients | 作者: | JENQ-WEN HUANG Yang C.-Y. Wu H.-Y. KAO-LANG LIU CHI-TING SU CHO-KAI WU JEN-KUANG LEE CHIH-KANG CHIANG HUI-TENG CHENG Lien Y.-C. KUAN-YU HUNG |
公開日期: | 2013 | 卷: | 12 | 期: | 1 | 起(迄)頁: | 86 | 來源出版物: | Cardiovascular Diabetology | 摘要: | Background: In the general population, metabolic syndrome (MetS) is correlated with visceral fat and a risk factor for cardiovascular disease (CVD); however, little is known about the significance of abdominal fat and its association with inflammation and medication use in peritoneal dialysis (PD) patients. We investigated the relationship of visceral fat area (VFA) with C-reactive protein (CRP) levels and medication use in PD patients and followed their clinical outcomes.Methods: In a prospective study from February 2009 to February 2012, we assessed diabetes mellitus (DM) status, clinical and PD-associated characteristics, medication use, CRP levels, components of MetS, and VFA in 183 PD patients. These patients were categorized into 3 groups based on MetS and DM status: non-MetS (group 1, n = 73), MetS (group 2, n = 65), and DM (group 3, n = 45). VFA was evaluated by computed tomography (CT) and corrected for body mass index (BMI).Results: Patients in group 1 had smaller VFAs than patients in groups 2 and 3 (3.2 ± 1.8, 4.6 ± 1.9, and 4.9 ± 2.0 cm2/[kg/m2], respectively, P < 0.05) and lower CRP levels (0.97 ± 2.31, 1.27 ± 2.57, and 1.11 ± 1.35 mg/dL, respectively, P < 0.05). VFA increased with the number of criteria met for MetS. After adjusting for age, body weight, and sex, CRP and albumin levels functioned as independent positive predictors of VFA; on other hand, the use of renin-angiotensin system blockers was inversely correlated with VFA in PD patients without DM. In the survival analysis, DM patients (group 3) had the poorest survival among the 3 groups, but no significant differences were found between groups 1 and 2.Conclusion: This study showed that VFA and MetS are associated with CRP levels but cannot predict survival in PD patients without DM. The complex relationship of nutritional parameters to VFA and MetS may explain these results. The type of antihypertensive medication used was also associated with the VFA. The mechanisms behind these findings warrant further investigation. ? 2013 Huang et al.; licensee BioMed Central Ltd. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/479449 | ISSN: | 1475-2840 | DOI: | 10.1186/1475-2840-12-86 | SDG/關鍵字: | albumin; antihypertensive agent; beta adrenergic receptor blocking agent; C reactive protein; glucose; hydroxymethylglutaryl coenzyme A reductase inhibitor; triacylglycerol; antihypertensive agent; autacoid; biological marker; C reactive protein; abdominal fat; adult; article; blood sampling; body mass; chronic kidney disease; clinical feature; computer assisted tomography; diabetes mellitus; dialysate; disease association; female; hemodialysis patient; human; hypertension; inflammation; intraabdominal fat; major clinical study; male; metabolic syndrome X; nutritional parameters; outcome assessment; peritoneal dialysis; prospective study; renin angiotensin aldosterone system; survival; abdominal fat; adverse effects; aged; blood; diabetes mellitus; hypertension; immunology; inflammation; Kaplan Meier method; metabolic syndrome X; middle aged; mortality; multidetector computed tomography; nutritional status; obesity; Obesity, Abdominal; pathophysiology; peritoneal dialysis; radiography; risk factor; time; treatment outcome; Abdominal Fat; Adiposity; Adult; Aged; Antihypertensive Agents; Biological Markers; C-Reactive Protein; Diabetes Mellitus; Female; Humans; Hypertension; Inflammation; Inflammation Mediators; Kaplan-Meier Estimate; Male; Metabolic Syndrome X; Middle Aged; Multidetector Computed Tomography; Nutritional Status; Obesity, Abdominal; Peritoneal Dialysis; Prospective Studies; Risk Factors; Time Factors; Treatment Outcome |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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