https://scholars.lib.ntu.edu.tw/handle/123456789/479468
標題: | Primary aldosteronism: Changes in cystatin C-based kidney filtration, proteinuria, and renal duplex indices with treatment | 作者: | VIN-CENT WU Wang S.-M. SHUO-MENG WANG KAO-LANG LIU KUO-HOW HUANG YEN-HUNG LIN TZONG-SHINN CHU Chang H.-W. Lin C.-Y. CHIA-TI TSAI LIAN-YU LIN SHIH-CHIEH CHUEH Kao T.-W. YUNG-MING CHEN WEN-CHIH CHIANG TUN-JUN TSAI YI-LWUN HO SHUEI-LIONG LIN Wang W.-J. KWAN-DUN WU |
公開日期: | 2011 | 卷: | 29 | 期: | 9 | 起(迄)頁: | 1778-1786 | 來源出版物: | Journal of Hypertension | 摘要: | Objectives: To obtain information about the effect of prolonged aldosterone excess on kidney function. Methods: We determined kidney function changes defined by cystatin C-based estimations of glomerular filtration rate (CysC-GFR). Pretreatment proteinuria and intrarenal Doppler velocimetric indices in primary aldosteronism were examined and followed after adrenalectomy or spironolactone treatment. Results: This prospective, multicenter study included 130 primary aldosteronism patients (56 men; age, 49.9±13.4 years: 100 with adenoma and 30 with idiopathic hyperaldosteronism) and 73 essential hypertension patients (36 men; age, 51.4±14.8 years) as controls. Patients with primary aldosteronism had higher CysC-GFR (P<0.05) and heavier proteinuria (0.042) than those with essential hypertension. With primary aldosteronism, a higher aldosterone-renin ratio (odds ratio, OR=7.85, P=0.008) was independently related to pretreatment CysC-GFR. The factors related to pretreatment proteinuria included CysC-GFR (OR,-0.006, P=0.001), plasma aldosterone concentration (OR, 0.004, P=0.002), and duration of hypertension (OR, 0.016, P=0.032). Duration of hypertension was also independently correlated with the pretreatment resistive index among primary aldosteronism patients (OR, 0.004, P=0.035). CysC-GFR (all, P<0.05), proteinuria (P<0.001), and resistive index (P<0.001) decreased 1 year after adrenalectomy but not with spironolactone treatment. Conclusion |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/479468 | ISSN: | 0263-6352 | DOI: | 10.1097/HJH.0b013e3283495cbb | SDG/關鍵字: | aldosterone; cystatin C; spironolactone; adenoma; adrenalectomy; adult; aldosterone blood level; article; controlled study; disease duration; essential hypertension; female; glomerulus filtration; glomerulus filtration rate; human; kidney function; laser Doppler flowmetry; major clinical study; male; multicenter study; primary hyperaldosteronism; priority journal; prospective study; protein depletion; proteinuria; renin angiotensin aldosterone system |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。