https://scholars.lib.ntu.edu.tw/handle/123456789/479476
標題: | Factors influencing left ventricular mass regression in patients with primary aldosteronism post adrenalectomy | 作者: | YEN-HUNG LIN KUO-HOW HUANG JEN-KUANG LEE SHUO-MENG WANG RUOH-FANG YEN VIN-CENT WU Chung S.-D. KAO-LANG LIU SHIH-CHIEH CHUEH LIAN-YU LIN YI-LWUN HO MING-FONG CHEN KWAN-DUN WU Chang H.-W. Hu F.-C. YUNG-MING CHEN Kuo C.-C. CHING-CHU LU Chang F.-C. Shih-Cheng Liao WEI-CHOU LIN Hsieh B.-S. |
公開日期: | 2011 | 卷: | 12 | 期: | 1 | 起(迄)頁: | 48-53 | 來源出版物: | JRAAS - Journal of the Renin-Angiotensin-Aldosterone System | 摘要: | Background. Primary aldosteronism (PA) is a type of secondary hypertension with prominent left ventricular hypertrophy (LVH). Unilateral aldosterone-producing adenoma (APA) is the most common subtype that can be cured by adrenalectomy. Objective. To investigate left ventricular structural change after surgery and the factors associated with the degree of LVH regression in patients with PA. Methods. We performed a retrospective analysis in the Taiwan Primary Aldosteronism Investigation (TAIPAI) database, including demography, biochemical data, echocardiography and medication. Results. From July 1994 to January 2007, 20 patients (8 men) with APA receiving adrenalectomy and having pre- and postoperative echocardiography were selected. After 21 ± 19 months post operation, the left ventricular wall thickness and left ventricular mass index (LVMI) decreased significantly. The decrease of LVMI is significant only in patients who had LVH before operation. In analysis of factors associated with net LVMI decrease (ΔLVMI; post-operative LVMI - pre-operative LVMI), only pre-operative LVMI (r = -.783, p <.001), and ΔSBP (r =.472, p =.036) significantly correlated with ΔLVMI. In conclusion, LVH in PA could be significantly reversed by adrenalectomy. Pre-operative LVMI and ΔSBP were associated with the degree of LVMI decrease. Conclusion. LVH in PA could be significantly reversed by adrenalectomy. Pre-operative LVMI and ΔSBP were associated with the degree of LVMI decrease. ? The Authors, 2010. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/479476 | ISSN: | 1470-3203 | DOI: | 10.1177/1470320310376424 | SDG/關鍵字: | aldosterone; alpha adrenergic receptor blocking agent; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; calcium channel blocking agent; creatinine; dipeptidyl carboxypeptidase inhibitor; diuretic agent; potassium; renin; adrenalectomy; adult; aldosterone release; article; blood pressure measurement; body mass; cardiovascular risk; clinical article; clinical assessment; computer assisted tomography; concentration (parameters); correlation coefficient; data base; disease severity; echocardiography; female; heart left ventricle hypertrophy; heart left ventricle mass; histopathology; human; hypertension; left ventricular mass regression; male; outcome assessment; plasma renin activity; postoperative period; preoperative evaluation; primary hyperaldosteronism; retrospective study; Adrenalectomy; Female; Heart Ventricles; Humans; Hyperaldosteronism; Hypertrophy, Left Ventricular; Male; Middle Aged |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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