https://scholars.lib.ntu.edu.tw/handle/123456789/479670
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee Y.-L. | en_US |
dc.contributor.author | Lu M.-C. | en_US |
dc.contributor.author | PEI-LAN SHAO | en_US |
dc.contributor.author | Lu P.-L. | en_US |
dc.contributor.author | Chen Y.-H. | en_US |
dc.contributor.author | Cheng S.-H. | en_US |
dc.contributor.author | Ko W.-C. | en_US |
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | Wu T.-S. | en_US |
dc.contributor.author | Yen M.-Y. | en_US |
dc.contributor.author | Wang L.-S. | en_US |
dc.contributor.author | Liu C.-P. | en_US |
dc.contributor.author | Lee W.-S. | en_US |
dc.contributor.author | Shi Z.-Y. | en_US |
dc.contributor.author | Chen Y.-S. | en_US |
dc.contributor.author | Wang F.-D. | en_US |
dc.contributor.author | Tseng S.-H. | en_US |
dc.contributor.author | Lin C.-N. | en_US |
dc.contributor.author | Chen Y.-H. | en_US |
dc.contributor.author | WANG-HUEI SHENG | en_US |
dc.contributor.author | Lee C.-M. | en_US |
dc.contributor.author | Liao M.-H. | en_US |
dc.contributor.author | PO-REN HSUEH | en_US |
dc.creator | PO-REN HSUEH;Liao M.-H.;Lee C.-M.;Sheng W.-H.;Chen Y.-H.;Lin C.-N.;Tseng S.-H.;Wang F.-D.;Chen Y.-S.;Shi Z.-Y.;Lee W.-S.;Liu C.-P.;Wang L.-S.;Yen M.-Y.;Wu T.-S.;Lin C.-Y.;Ko W.-C.;Cheng S.-H.;Chen Y.-H.;Lu P.-L.;Shao P.-L.;Lu M.-C.;Lee Y.-L. | - |
dc.date.accessioned | 2020-03-27T05:28:22Z | - |
dc.date.available | 2020-03-27T05:28:22Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0924-8579 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/479670 | - |
dc.description.abstract | Multicentre surveillance of antimicrobial susceptibility of clinically important Gram-negative bacteria (GNB) from 16 Taiwanese hospitals was performed. Escherichia coli (n = 398), Klebsiella pneumoniae (n = 346), Pseudomonas aeruginosa (n = 252) and Acinetobacter baumannii complex (ABC) (n = 188) bloodstream isolates, non-typhoidal Salmonella (n = 230) and Shigella flexneri (n = 18) from various sources were collected. Antimicrobial MICs were determined using broth microdilution. Genes encoding K. pneumoniae carbapenemases (KPCs), New Delhi metallo-β-lactamases (NDMs), Verona integron-encoded metallo-β-lactamase (VIM), OXA-48-like carbapenemase (OXA-48) as well as mcr-1–5 genes were detected by molecular methods. Rates of carbapenem non-susceptibility were 2.8%, 9.0%, 0.4%, 0%, 10.3% and 48.8% for E. coli, K. pneumoniae, Salmonella, Shigella, P. aeruginosa and ABC, respectively. For carbapenemases, one (0.3%) E. coli harboured blaNDM-1. Fifteen (4.3%), two (0.6%) and two (0.6%) K. pneumoniae contained blaKPC, blaOXA-48 and blaVIM, respectively. Two (0.5%) E. coli and fourteen (4.0%) K. pneumoniae were non-wild-type according to the colistin MIC. Among Enterobacteriaceae with a colistin MIC ? 2 mg/L, mcr-1 was detected in one E. coli, two K. pneumoniae and three Salmonella spp. All three mcr-1-positive Salmonella isolates were collected from community-acquired infections; none of the six mcr-1-positive Enterobacteriaceae were carbapenem-resistant. Carbapenem resistance has increased among clinically important GNB, especially among hospital-acquired infections. blaKPC, especially the blaKPC-2 variant, was detected in approximately one-half of the carbapenem-resistant K. pneumoniae isolates in this study. Although resistance rates to colistin remained low among Enterobacteriaceae, the finding of mcr-1 from different species raises concern of potential dissemination. ? 2019 | - |
dc.relation.ispartof | International Journal of Antimicrobial Agents | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | carbapenem; carbapenemase; colistin; metallo beta lactamase; antiinfective agent; carbapenem derivative; colistin; Acinetobacter baumannii; antibiotic resistance; antibiotic sensitivity; Article; bacterial gene; bacterium isolate; bacterium isolation; broth dilution; community acquired infection; controlled study; disease surveillance; Escherichia coli; gene; gene identification; Gram negative bacterium; Klebsiella pneumoniae; mcr 1 gene; mcr 2 gene; mcr 3 gene; mcr 4 gene; mcr 5 gene; minimum inhibitory concentration; nonhuman; priority journal; Pseudomonas aeruginosa; Salmonella; Shigella flexneri; Taiwan; clinical trial; drug effect; epidemiological monitoring; genotype; Gram negative bacterium; Gram negative infection; hospital; human; isolation and purification; microbial sensitivity test; microbiology; multicenter study; prevalence; Anti-Bacterial Agents; Carbapenems; Colistin; Drug Resistance, Bacterial; Epidemiological Monitoring; Genes, Bacterial; Genotype; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Hospitals; Humans; Microbial Sensitivity Tests; Prevalence; Taiwan | - |
dc.title | Nationwide surveillance of antimicrobial resistance among clinically important Gram-negative bacteria, with an emphasis on carbapenems and colistin: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART) in 2018 | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.ijantimicag.2019.06.009 | - |
dc.identifier.pmid | 31202925 | - |
dc.identifier.scopus | 2-s2.0-85071363334 | - |
dc.relation.pages | 318-328 | - |
dc.relation.journalvolume | 54 | - |
dc.relation.journalissue | 3 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Pediatrics-NTUHHC | - |
crisitem.author.dept | Laboratory Medicine-NTUHHC | - |
crisitem.author.dept | Internal Medicine | - |
crisitem.author.dept | Medical Education-NTUH | - |
crisitem.author.dept | Internal Medicine-NTUH | - |
crisitem.author.dept | Laboratory Medicine | - |
crisitem.author.dept | Laboratory Medicine-NTUH | - |
crisitem.author.orcid | 0000-0003-3334-1330 | - |
crisitem.author.orcid | 0000-0002-5605-7853 | - |
crisitem.author.orcid | 0000-0002-7502-9225 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | NTU Hsin-Chu Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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