https://scholars.lib.ntu.edu.tw/handle/123456789/479690
標題: | Nanoparticles in the treatment of infections caused by multidrug-resistant organisms | 作者: | Lee N.-Y. Ko W.-C. PO-REN HSUEH |
公開日期: | 2019 | 卷: | 10 | 起(迄)頁: | 1153 | 來源出版物: | Frontiers in Pharmacology | 摘要: | Nanotechnology using nanoscale materials is increasingly being utilized for clinical applications, especially as a new paradigm for infectious diseases. Infections caused by multidrug-resistant organisms (MDROs) are emerging as causes of morbidity and mortality worldwide. Antibiotic options for infections caused by MDROs are often limited. These clinical challenges highlight the critical demand for alternative and effective antimicrobial strategies. Nanoparticles (NPs) can penetrate the cell membrane of pathogenic microorganisms and interfere with important molecular pathways, formulating unique antimicrobial mechanisms. In combination with optimal antibiotics, NPs have demonstrated synergy and may aid in limiting the global crisis of emerging bacterial resistance. In this review, we summarized current research on the broad classification of the NPs that have shown in vitro antimicrobial activity against MDROs, including the ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). The pharmacokinetics and pharmacodynamic characteristics of NPs and bacteria-resistant mechanisms to NPs were also discussed. Copyright ? 2019 Lee, Ko and Hsueh. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/479690 | ISSN: | 1663-9812 | DOI: | 10.3389/fphar.2019.01153 | SDG/關鍵字: | aluminum nanoparticle; aluminum oxide nanoparticle; ampicillin; antiinfective agent; ceftazidime; ciprofloxacin; clindamycin; copper nanoparticle; erythromycin; gold nanoparticle; iron oxide; kanamycin; magnesium oxide nanoparticle; nanoparticle; polymyxin B; quinolone derivative; silica nanoparticle; silver nanoparticle; streptomycin; tetracycline; titanium dioxide nanoparticle; ultrasmall superparamagnetic iron oxide; unclassified drug; vancomycin; Acinetobacter baumannii; antibacterial activity; antibiotic resistance; bacterial strain; bacterium; bacterium isolate; biocompatibility; bone marrow toxicity; colon disease; concentration response; drug absorption; drug clearance; drug conjugation; drug delivery system; drug elimination; drug mechanism; drug penetration; drug potentiation; Enterobacter; Enterococcus faecium; Escherichia coli infection; human; immune response; in vitro study; Klebsiella pneumoniae; liver injury; liver toxicity; lung injury; lymphatic system disease; membrane potential; methicillin resistant Staphylococcus aureus; minimum inhibitory concentration; multidrug resistance; multidrug resistance organism; multidrug resistant Escherichia coli; nephrotoxicity; neurotoxicity; nonhuman; particle size; physical chemistry; protein synthesis; Pseudomonas aeruginosa; Review; RNA synthesis; spleen disease; spleen injury; Staphylococcus aureus; surface charge; surface property; vancomycin resistant Enterococcus; zeta potential |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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