https://scholars.lib.ntu.edu.tw/handle/123456789/479701
標題: | Carbapenem-resistant enterobacteriaceae infections: Taiwan aspects | 作者: | Jean S.-S. Lee N.-Y. Tang H.-J. Lu M.-C. Ko W.-C. PO-REN HSUEH |
公開日期: | 2018 | 卷: | 9 | 期: | NOV | 起(迄)頁: | 2888 | 來源出版物: | Frontiers in Microbiology | 摘要: | Carbapenem-resistant Enterobacteriaceae (CRE), a major resistance concern emerging during the last decade because of significantly compromising the efficacy of carbapenem agents, has currently become an important focus of infection control. Many investigations have shown a high association of CRE infections with high case-fatality rates. In Taiwan, a few surveys observed that a significant proportion (29–47%) of the CR-Klebsiella pneumoniae isolates harbored a plasmidic allele encoding K. pneumoniae carbapenemases (KPC, especially KPC-2). A significant increase in the number of oxacillinase (OXA)-48-like carbapenemases among CR-K. pneumoniae isolates was observed between 2012 and 2015. By striking contrast, isolates of CR-Escherichia coli and CR-Enterobacter species in Taiwan had a much lower percentage of carbapenemase production than CR-K. pneumoniae isolates. This differs from isolates found in China as well as in the India subcontinent. Apart from the hospital setting, CRE was also cultured from the inpatients from communities or long-term care facilities (LTCF). Therefore, implementation of regular CRE screening of LTCF residents, strict disinfectant use in nursing homes and hospital settings, and appropriate control of antibiotic prescriptions is suggested to alleviate the spread of clinical CRE isolates in Taiwan. Although there are some promising new antibiotics against CRE, such as ceftazidime-avibactam, meropenem-vaborbactam, aztreonam-avibactam and cefiderocol, these agents are not available in Taiwan currently. Therefore, in order to effectively decrease case-fatality rates among patients with the infections owing to carbapenemase-producing CRE isolates, combination antibiotic schemes, including colistin (or amikacin) and/or tigecycline in combination with an anti-pseudomonal carbapenem agent, remain the mainstay for treating clinical CRE infections. ? 2018 Jean, Lee, Tang, Lu, Ko and Hsueh. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/479701 | ISSN: | 1664-302X | DOI: | 10.3389/fmicb.2018.02888 | SDG/關鍵字: | amikacin; avibactam; avibactam plus ceftazidime; aztreonam; beta lactamase AmpC; carbapenemase; cefiderocol; ceftolozane plus tazobactam; colistin; disinfectant agent; eravacycline; ertapenem; fosfomycin; imipenem; meropenem plus vaborbactam; plazomicin; relebactam; resolvase; tigecycline; transposase; abdominal infection; antibiotic resistance; antibiotic sensitivity; bacterial colonization; bacterium isolate; bibliographic database; carbapenem-resistant Enterobacteriaceae; clinical effectiveness; clinical trial (topic); combination drug therapy; community acquired infection; disease surveillance; disk diffusion; Enterobacter; Enterobacter cloacae; Enterobacteriaceae infection; Escherichia coli; evidence based medicine; extended spectrum beta lactamase producing Enterobacteriaceae; genetic code; genetic screening; geographical variation (species); health survey; human; infection control; Klebsiella oxytoca; Klebsiella pneumoniae; long term care; minimum inhibitory concentration; monotherapy; mortality rate; multiplex polymerase chain reaction; nonhuman; phenotype; prevalence; randomized controlled trial (topic); Review; Taiwan; transposon; urinary tract infection |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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