https://scholars.lib.ntu.edu.tw/handle/123456789/480028
標題: | The impact of oral herpes simplex virus infection and candidiasis on chemotherapy-induced oral mucositis among patients with hematological malignancies | 作者: | YIN-KAI CHEN HSIN-AN HOU Chow J.-M. YEE-CHUN CHEN PO-REN HSUEH HWEI-FANG TIEN |
公開日期: | 2011 | 卷: | 30 | 期: | 6 | 起(迄)頁: | 753-759 | 來源出版物: | European Journal of Clinical Microbiology and Infectious Diseases | 摘要: | The aim of this study was to evaluate the influences of oral candidiasis and herpes simplex virus 1 (HSV-1) infections in chemotherapy-induced oral mucositis (OM). The medical records of 424 consecutive patients with hematological malignancies who had received chemotherapy at a medical center in Taiwan from January 2006 to November 2007 were retrospectively reviewed. The results of swab cultures of fungus and HSV-1 for OM were correlated with associated clinical features. Younger age, myeloid malignancies, and disease status other than complete remission before chemotherapy were significantly correlated with the development of OM. Risks of fever (p<0.001) and bacteremia were higher in patients with OM. Among 467 episodes of OM with both swab cultures available, 221 were non-infection (47.3%) and 246 were related to either fungal infections, HSV-1 infections, or both (52.7%); of the 246 episodes, 102 were associated with fungal infections alone (21.8%), 98 with HSV-1 infections alone (21%), and 46 with both infections (9.9%). Patients who had received antifungal agents prior to OM occurrence tended to have HSV-1 infection (p<0.001). Our results suggest that Candida albicans and HSV-1 play an important role in chemotherapy-induced OM in patients with hematological malignancies. ? 2011 Springer-Verlag. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480028 | ISSN: | 0934-9723 | DOI: | 10.1007/s10096-010-1148-z | SDG/關鍵字: | antifungal agent; antineoplastic agent; antivirus agent; lidocaine; acute biphenotypic leukemia; acute granulocytic leukemia; acute lymphoblastic leukemia; adult; aged; article; bacteremia; Candida albicans; candidiasis; chronic myeloid leukemia; clinical feature; controlled study; disease association; female; fever; fungus culture; gargle; health status; hematologic malignancy; herpes simplex; Herpes simplex virus 1; Hodgkin disease; human; infection risk; leukemia remission; major clinical study; male; multiple myeloma; mycosis; myelodysplastic syndrome; myeloproliferative disorder; neutrophil count; nonhodgkin lymphoma; priority journal; retrospective study; smear; stomatitis; Adolescent; Adult; Aged; Aged, 80 and over; Candida albicans; Candidiasis, Oral; Drug Therapy; Female; Hematologic Neoplasms; Herpesvirus 1, Human; Humans; Male; Middle Aged; Mouth Mucosa; Prevalence; Retrospective Studies; Stomatitis; Stomatitis, Herpetic; Taiwan; Young Adult |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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