https://scholars.lib.ntu.edu.tw/handle/123456789/480294
標題: | Risk of recurrent nontyphoid Salmonella bacteremia in HIV-infected patients in the era of highly active antiretroviral therapy and an increasing trend of fluoroquinolone resistance. | 作者: | CHIEN-CHING HUNG Hung M.N. PO-REN HSUEH SUI-YUAN CHANG Chen M.Y. SZU-MIN HSIEH WANG-HUEI SHENG HSIN-YUN SUN YU-TSUNG HUANG Lo Y.C. Hsiao C.F. SHAN-CHWEN CHANG |
公開日期: | 2007 | 卷: | 45 | 期: | 5 | 起(迄)頁: | e60-67 | 來源出版物: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America | 摘要: | BACKGROUND: Risk of recurrent nontyphoid Salmonella (NTS) bacteremia and trends of antimicrobial resistance of NTS remain unknown in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART). METHODS: Ninety-three patients who received a diagnosis of NTS bacteremia from June 1994 through June 2006 were prospectively followed up. Incidence of recurrent NTS bacteremia was compared between the pre-HAART era (June 1994-March 1997) and the HAART era (April 1997-June 2006). Prevalence of antimicrobial resistance was compared among the NTS isolates obtained in the pre-HAART era, the early HAART era (April 1997-June 2002), and the late HAART era (July 2002-June 2006). RESULTS: Compared with patients enrolled in the pre-HAART era, patients who received HAART had an incidence of recurrent NTS bacteremia that was significantly reduced by 96%; the incidence of recurrent NTS bacteremia was 2.56 cases per 100 person-years in the HAART era, compared with 70.56 cases per 100 person-years in the pre-HAART era (rate ratio, 0.036; 95% confidence interval, 0.012-0.114; P<.001). In the HAART era, the incidence of recurrent NTS bacteremia did not increase among patients receiving fluoroquinolone prophylaxis for |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480294 | ISSN: | 1537-6591 | DOI: | 10.1086/520681 | SDG/關鍵字: | antiretrovirus agent; quinolone derivative; adult; article; bacteremia; comparative study; female; follow up; highly active antiretroviral therapy; human; Human immunodeficiency virus infection; incidence; male; microbiological examination; middle aged; multidrug resistance; recurrent disease; salmonellosis; Taiwan; Adult; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Bacteremia; Drug Resistance, Multiple, Bacterial; Female; Fluoroquinolones; Follow-Up Studies; HIV Infections; Humans; Incidence; Male; Microbial Sensitivity Tests; Middle Aged; Recurrence; Salmonella Infections; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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