https://scholars.lib.ntu.edu.tw/handle/123456789/480298
標題: | Bacteremia caused by Salmonella enterica serotype Choleraesuis in Taiwan | 作者: | Jean S.-S. Wang J.-Y. PO-REN HSUEH |
公開日期: | 2006 | 卷: | 39 | 期: | 5 | 起(迄)頁: | 358-365 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Since 1995, there has been a steady increase in the number of reported cases of Salmonella enterica serotype Choleraesuis (S. Choleraesuis) sepsis in Taiwan. Representative Taiwanese survey data from 1996 to 2004 revealed that these adult patients with S. Choleraesuis bacteremia presented with primary bacteremia (57%, especially immunocompromised hosts), mycotic aneurysm (16%), and fever (86%) predominantly. S. Choleraesuis septicemia demonstrated a higher invasion index (with secondary involved sites) than other Salmonella spp. In swine experiments, the inoculation dose of 103 colony forming units S. Choleraesuis was cleared without apparent sequelae. Transmission of specific strains (with mutations of GyrA and parC, subsequently resistance to fluoroquinolones) from swine, and the acquisition of genes (CMY-2, AmpC complex) encoding beta-lactamases (with resistance to extended-spectrum cephalosporins) have been implicated in the evolution of multiresistant phenotypes of S. Choleraesuis. The virulence plasmid of S. Choleraesuis (pSCV), and other genes mediating adhesion to the epithelial cell membrane of the gastrointestinal tract, were considered important pathogenic factors for S. Choleraesuis. Vaccines for domestic animals combined with effective controls on antibiotic use offer the greatest potential to control the increasing impact of S. Choleraesuis on humans. ? 2006 Journal of Microbiology, Immunology and Infection. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480298 | ISSN: | 1684-1182 | SDG/關鍵字: | ampicillin; bacterial vaccine; beta lactamase AmpC; cefotaxime; ceftriaxone; chloramphenicol; cotrimoxazole; DNA topoisomerase (ATP hydrolysing) A; enrofloxacin; protein ParC; quinolone derivative; antibiotic resistance; bacteremia; bacterial gene; clinical feature; disease transmission; gene mutation; human; mycotic aneurysm; nonhuman; prophylaxis; review; Salmonella choleraesuis; Salmonella enterica; salmonellosis; septicemia; Taiwan; Aneurysm, Infected; Animals; Anti-Bacterial Agents; Bacteremia; beta-Lactamases; Cephalosporins; Drug Resistance, Multiple, Bacterial; Evolution; Fever; Fluoroquinolones; Humans; Plasmids; Prevalence; Salmonella enterica; Salmonella Infections; Species Specificity; Swine; Taiwan; Virulence; Virulence Factors |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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