https://scholars.lib.ntu.edu.tw/handle/123456789/480411
標題: | Re-emergence of meningococcal disease in Taiwan: Circulation of domestic clones of Neisseria meningitidis in the 2001 outbreak | 作者: | PO-REN HSUEH LEE-JENE TENG Lin T.-Y. Chen K.-T. Hsu H.-M. Twu S.-J. Ho S.-W. KWEN-TAY LUH |
公開日期: | 2004 | 卷: | 132 | 期: | 4 | 起(迄)頁: | 637-645 | 來源出版物: | Epidemiology and Infection | 摘要: | The annual incidence of meningococcal disease (meningitis and septicaemia) in Taiwan was 0.94/105 population in 1953. It then declined to below 0.001 from 1980 to 1987, and re-emerged in 2000 with a rate of 0.07/105 population. In 2001 there was a further increase in incidence (43 cases, 0.19/105). Of 43 isolates of Neisseria meningitidis available for this study, including 41 from patients treated in 2001, three (7.0%) were penicillin insensitive (MIC ?0.12 μg/ml), though all were β-lactamase negative; 16 (37.2%) were resistant to trimethoprim - sulphamethoxazole (MIC ?4/76 μg/ml). Serogrouping and genotype analysis revealed nine domestic clones. None of the 43 patients had any relationship (travel or contact history) with the 2000 or 2001 Hajj pilgrimage. Epidemiological information and typing results suggested wide dissemination of a limited number of domestic clones of N. meningitidis, manifesting as serogroups W-135, B and Y. Two clones of serogroup W-135 involved in the outbreak were genetically distinct from the 2000 or 2001 Hajj-related W-135 clone. ? 2004 Cambridge University Press. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480411 | ISSN: | 0950-2688 | DOI: | 10.1017/S0950268804002316 | SDG/關鍵字: | ampicillin; beta lactamase; cefepime; ceftriaxone; chloramphenicol; ciprofloxacin; clarithromycin; cotrimoxazole; erythromycin; fropenem; gatifloxacin; imipenem; meropenem; moxifloxacin; penicillin G; rifampicin; tigecycline; antiinfective agent; bacterial DNA; primer DNA; antibiotic resistance; antibiotic sensitivity; article; bacterial transmission; bacterium identification; bacterium isolate; contact examination; controlled study; epidemic; epidemiological data; genotype; human; incidence; major clinical study; meningococcosis; minimum inhibitory concentration; Neisseria meningitidis; polymerase chain reaction; population research; pulsed field gel electrophoresis; random amplified polymorphic DNA; religion; Taiwan; travel; adolescent; adult; child; drug effect; epidemic; epidemic meningitis; female; genetics; infant; male; microbiological examination; microbiology; newborn; preschool child; season; Taiwan; Adolescent; Adult; Anti-Bacterial Agents; Child; Child, Preschool; Disease Outbreaks; DNA Primers; DNA, Bacterial; Drug Resistance, Bacterial; Female; Genotype; Humans; Infant; Infant, Newborn; Male; Meningitis, Meningococcal; Microbial Sensitivity Tests; Neisseria meningitidis; Polymerase Chain Reaction; Seasons; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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