https://scholars.lib.ntu.edu.tw/handle/123456789/480441
標題: | Association of antibiotic utilization measures and reduced incidence of infections with extended-spectrum β-lactamase-producing organisms | 作者: | Lan C.-K. PO-REN HSUEH Wong W.-W. Fung C.-P. Lau Y.-T. Yeung J.Y.K. Young G.T. Su C.-C. |
公開日期: | 2003 | 卷: | 36 | 期: | 3 | 起(迄)頁: | 182-186 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | With the overuse of expanded-spectrum cephalosporins, especially ceftazidime, outbreaks of extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae and Escherichia coli infections have been reported. In this prospective observational study, we demonstrated that the addition of piperacillin/tazobactam to the formulary and the restriction of ceftazidime were associated with a decrease in the percentage of ceftazidime-resistant isolates. When the use of ceftazidime decreased by 96.43%, and the use of piperacillin/tazobactam increased by over 50% during the 9-month study period, a concomitant decrease was found in the percentage of colonization and infection by ESBL-producing E. coli or K. pneumoniae in patients admitted to the intensive care unit. Results from this 9-month intervention study support the concept that levels of local and institutional use of ceftazidime are of substantial importance to the emergence and persistence of endemic ceftazidime-resistant K. pneumoniae. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480441 | ISSN: | 0253-2662 | SDG/關鍵字: | ampicillin; antibiotic agent; beta lactamase; cefepime; cefoxitin; ceftazidime; ceftriaxone; cephalosporin derivative; gentamicin; imipenem; minocycline; piperacillin; piperacillin plus tazobactam; sultamicillin; antibiotic resistance; article; bacterial colonization; bacterial infection; bacterium isolate; drug utilization; endemic disease; epidemic; Escherichia coli; human; incidence; intensive care unit; Klebsiella pneumoniae; major clinical study; nonhuman; persistent infection; prospective study; Anti-Bacterial Agents; beta-Lactamases; Ceftazidime; Cephalosporin Resistance; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Female; Humans; Klebsiella Infections; Klebsiella pneumoniae; Male; Penicillanic Acid; Piperacillin; Prospective Studies; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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