https://scholars.lib.ntu.edu.tw/handle/123456789/480851
標題: | Immunological characterization of anti-Mia, a red blood cell alloantibody, in Taiwan | 作者: | SHYH-CHYI LO Chang J.-S. Lin S.W.-S. Lin D.-T. |
公開日期: | 2002 | 卷: | 83 | 期: | 2 | 起(迄)頁: | 162-164 | 來源出版物: | Vox Sanguinis | 摘要: | Background and Objectives: The red blood cell Mi III phenotype is prevalent in Asia, and its corresponding alloantibody, anti-Mia, has been reported to cause haemolytic transfusion reactions and haemolytic disease of the newborn. However, a complete picture of the immunological characteristics of anti-Mia is still lacking. We therefore conducted a systematic study to evaluate the potential clinical significance of this antibody. Materials and Methods: From April 1999 to March 2000, we identified 60 sera containing anti-Mia among pretransfusion samples at a teaching hospital in Taiwan. These antibodies were tested for immunoglobulin class, thermal range and activity in a monocyte monolayer assay. Results: Thirty-four (57%) of the antibodies were immunoglobulin M (IgM), and 15 retained their activity at 37°C. Of those that were immunoglobulin G (IgG), 96% were of subclasses IgG1 and/or IgG3. Monocyte monolayer assay studies showed that 69% (18/26) of the IgG anti-Mia sera were reactive. Conclusions: Our study justifies the implementation of anti-Mia screening in Taiwan. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/480851 | ISSN: | 0042-9007 | DOI: | 10.1046/j.1423-0410.2002.00212.x | SDG/關鍵字: | alloantibody; erythrocyte antibody; immunoglobulin G; immunoglobulin G1; immunoglobulin G3; immunoglobulin M; Miltenberger antibody; unclassified drug; antibody detection; antibody screening; article; blood group MNSs system; blood transfusion; clinical article; diagnostic value; human; monocyte; newborn hemolytic disease; phenotype; priority journal; screening test; Taiwan; thermal analysis; Erythrocytes; Humans; Immunoglobulins; Isoantibodies; Mass Screening; MNSs Blood-Group System; Phenotype; Taiwan |
顯示於: | 醫學院附設醫院 (臺大醫院) |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。