https://scholars.lib.ntu.edu.tw/handle/123456789/481373
標題: | Electroporation by concentric-type needle electrodes and arrays | 作者: | Kung Y. Lihachev A. Šatkauskas S. Lan K.-L. WEN-SHIANG CHEN |
公開日期: | 2017 | 出版社: | Elsevier B.V. | 卷: | 118 | 起(迄)頁: | 31-37 | 來源出版物: | Bioelectrochemistry | 摘要: | The efficacy of genomic medicine depends on gene transfer efficiency. In this area, electroporation has been found to be a highly promising method for physical gene transfer. However, electroporation raises issues related to electrical safety, tissue damage, and the number of required wounds. Concentric-type needle electrodes seek to address these issues by using a lower bias (10?V), a single wound, fewer processing steps, and a smaller working area (??10?mm3), thus offering greater accuracy and precision. Moreover, the needle can be arrayed to simultaneously treat several target regions. This paper proposes a novel method using concentric-type needle electrodes to improve the efficacy of genomic medicine in terms of electrical safety, human factor and usability engineering. ? 2017 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021912901&doi=10.1016%2fj.bioelechem.2017.06.014&partnerID=40&md5=1c7b2a2474099e494393155eb4d1b784 https://scholars.lib.ntu.edu.tw/handle/123456789/481373 |
ISSN: | 1567-5394 | DOI: | 10.1016/j.bioelechem.2017.06.014 | SDG/關鍵字: | Electrodes; Gene therapy; Gene transfer; Needles; Safety engineering; Safety factor; Usability engineering; Accuracy and precision; Electrical safety; Electroporation; Gene Delivery; Needle electrodes; Transfection; Transfer efficiency; Zebrafish; Genes; insulin; luciferin; plasmid DNA; animal experiment; Article; controlled study; current density; electric conductance; electroporation; gene transfer; human; mouse; needle electrode; nonhuman; rat; surface area; tissue injury; work environment; animal; devices; electrode; electroporation; genetics; needle; zebra fish; Animals; Electrodes; Electroporation; Gene Transfer Techniques; Mice; Needles; Zebrafish |
顯示於: | 醫學系 |
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