https://scholars.lib.ntu.edu.tw/handle/123456789/481377
標題: | Higher-order power harmonics of pulsed electrical stimulation modulates corticospinal contribution of peripheral nerve stimulation | 作者: | Chen C.-F. Bikson M. Chou L.-W. Shan C. Khadka N. WEN-SHIANG CHEN Fregni F. |
公開日期: | 2017 | 出版社: | Nature Publishing Group | 卷: | 7 | 起(迄)頁: | 43619 | 來源出版物: | Scientific Reports | 摘要: | It is well established that electrical-stimulation frequency is crucial to determining the scale of induced neuromodulation, particularly when attempting to modulate corticospinal excitability. However, the modulatory effects of stimulation frequency are not only determined by its absolute value but also by other parameters such as power at harmonics. The stimulus pulse shape further influences parameters such as excitation threshold and fiber selectivity. The explicit role of the power in these harmonics in determining the outcome of stimulation has not previously been analyzed. In this study, we adopted an animal model of peripheral electrical stimulation that includes an amplitude-adapted pulse train which induces force enhancements with a corticospinal contribution. We report that the electrical-stimulation-induced force enhancements were correlated with the amplitude of stimulation power harmonics during the amplitude-adapted pulse train. In an exploratory analysis, different levels of correlation were observed between force enhancement and power harmonics of 20-80 Hz (r = 0.4247, p = 0.0243), 100-180 Hz (r = 0.5894, p = 0.0001), 200-280 Hz (r = 0.7002, p < 0.0001), 300-380 Hz (r = 0.7449, p < 0.0001), 400-480 Hz (r = 0.7906, p < 0.0001), 500-600 Hz (r = 0.7717, p < 0.0001), indicating a trend of increasing correlation, specifically at higher order frequency power harmonics. This is a pilot, but important first demonstration that power at high order harmonics in the frequency spectrum of electrical stimulation pulses may contribute to neuromodulation, thus warrant explicit attention in therapy design and analysis. ? The Author(s) 2017. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014633688&doi=10.1038%2fsrep43619&partnerID=40&md5=ded8ed786ca0ef1a5f387c156839125b https://scholars.lib.ntu.edu.tw/handle/123456789/481377 |
ISSN: | 2045-2322 | DOI: | 10.1038/srep43619 | SDG/關鍵字: | animal model; attention; disease model; electrostimulation; exploratory research; human; nerve stimulation; neuromodulation; animal; biological model; computer simulation; electrophysiology; Leporidae; male; peripheral nerve; physiology; pyramidal tract; statistical model; Animals; Computer Simulation; Electric Stimulation; Electrophysiological Phenomena; Male; Models, Neurological; Models, Statistical; Peripheral Nerves; Pyramidal Tracts; Rabbits |
顯示於: | 醫學系 |
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