https://scholars.lib.ntu.edu.tw/handle/123456789/481409
標題: | Enhancement of the cytotoxicity and selectivity of doxorubicin to hepatoma cells by synergistic combination of galactose-decorated -poly(glutamic acid) nanoparticles and low-intensity ultrasound | 作者: | Tsai W.-B. Lai H.-Y. Lee J.-L. Lo C.-W. WEN-SHIANG CHEN |
公開日期: | 2014 | 出版社: | American Chemical Society | 卷: | 30 | 期: | 19 | 起(迄)頁: | 5510-5517 | 來源出版物: | Langmuir | 摘要: | Specific drug delivery to solid tumors remains one of the challenges in cancer therapy. The aim of this study was to combine three drug-targeting strategies, polymer-drug conjugate, ligand presentation and ultrasound treatment, to enhance the efficacy and selectivity of doxorubicin (DXR) to hepatoma cells. The conjugation of DXR to γ-poly(glutamic acids) (γ-PGA) decreased the cytotoxicity of DXR, while the conjugation of galactosamine (Gal) to the γ-PGA-DXR conjugate restored the cytotoxic efficacy of DXR on hepatoma cells due to increased uptake of DXR. Furthermore, low-intensity ultrasound treatment increased the cell-killing ability of γ-PGA-DXR conjugates by 20%. The in vitro results showed the potential of the γ-PGA-DXR-Gal conjugate for future clinical applications. ? 2014 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901036351&doi=10.1021%2fla500352g&partnerID=40&md5=b5395c3e147915dd6df3ed72abd45690 https://scholars.lib.ntu.edu.tw/handle/123456789/481409 |
ISSN: | 0743-7463 | DOI: | 10.1021/la500352g | SDG/關鍵字: | Amino acids; Cytotoxicity; Drug delivery; Ultrasonics; Cancer therapy; Clinical application; Drug-targeting; Hepatoma cells; Low intensity ultrasound; Polyglutamic acids; Synergistic combinations; Ultrasound treatments; Tumors; doxorubicin; galactose; nanoparticle; cell survival; chemistry; drug delivery system; drug effects; human; liver cell carcinoma; tumor cell culture; ultrasound; Carcinoma, Hepatocellular; Cell Survival; Doxorubicin; Drug Delivery Systems; Galactose; Humans; Nanoparticles; Tumor Cells, Cultured; Ultrasonics |
顯示於: | 醫學系 |
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