https://scholars.lib.ntu.edu.tw/handle/123456789/481667
標題: | Association between p21 codon 31 polymorphism and esophageal cancer risk in a Taiwanese population | 作者: | Wu M.-T. Wu D.-C. Hsu H.-K. Kao E.-L. Yang C.-H. JANG-MING LEE |
公開日期: | 2003 | 出版社: | Elsevier Ireland Ltd | 卷: | 201 | 期: | 2 | 起(迄)頁: | 175-180 | 來源出版物: | Cancer Letters | 摘要: | P21, which regulates the cell growth cycle, is crucial for normal growth and differentiation. One polymorphism in the p21 codon 31 produces variant proteins with an amino acid change (serine (ser) or arginine (arg)). Although several epidemiologic studies have examined the effect of this polymorphism on cancer risk, the findings remain inconclusive, which has motivated us to evaluate the relationship between p21 codon 31 polymorphism and esophageal cancer risk. In this study, 128 cases of esophageal squamous cell carcinoma and 178 control cases from two hospitals in southern Taiwan were genotyped. Frequencies of arg/arg, arg/ser and ser/ser were 23 (18.0%), 62 (48.4%) and 43 (33.6%) in carcinoma cases and 51 (28.6%), 84 (47.2%) and 43 (24.2%) in control cases, respectively. After factoring out other potential contributing factors, patients with ser/ser or arg/ser were 2.17 times more at risk (95% CI=1.03-4.56) for developing esophageal cancer than those with arg/arg. Males (n=274) were found to have a slightly stronger association (adjusted OR=2.45; 95% CI=1.03-5.80). Although the sample size is relatively small, these findings suggest that a codon 31 polymorphism in p21 may be associated with the development of esophageal cancer. ? 2003 Elsevier Ireland Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0242289470&doi=10.1016%2fS0304-3835%2803%2900469-5&partnerID=40&md5=595584f03f62581d7f0a92bbf6695ea7 https://scholars.lib.ntu.edu.tw/handle/123456789/481667 |
ISSN: | 0304-3835 | DOI: | 10.1016/S0304-3835(03)00469-5 | SDG/關鍵字: | protein p21; adult; aged; article; cancer risk; carcinogenesis; cell cycle; cell growth; codon; controlled study; esophagus cancer; female; genetic association; genetic polymorphism; genotype; high risk population; human; human tissue; male; priority journal; sex difference; squamous cell carcinoma; Taiwan |
顯示於: | 醫學系 |
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