https://scholars.lib.ntu.edu.tw/handle/123456789/481673
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wu M.-T. | en_US |
dc.contributor.author | Wang Y.-T. | en_US |
dc.contributor.author | Ho C.-K. | en_US |
dc.contributor.author | Wu D.-C. | en_US |
dc.contributor.author | Lee Y.-C. | en_US |
dc.contributor.author | Hsu H.-K. | en_US |
dc.contributor.author | Kao E.-L. | en_US |
dc.contributor.author | JANG-MING LEE | en_US |
dc.creator | Wu M.-T.;Wang Y.-T.;Ho C.-K.;Wu D.-C.;Lee Y.-C.;Hsu H.-K.;Kao E.-L.;Jang-Ming Lee | - |
dc.date.accessioned | 2020-03-31T03:59:51Z | - |
dc.date.available | 2020-03-31T03:59:51Z | - |
dc.date.issued | 2003 | - |
dc.identifier.issn | 0020-7136 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037211727&doi=10.1002%2fijc.10805&partnerID=40&md5=6660d0ea7a73d8041cbc93e85848ba2e | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/481673 | - |
dc.description.abstract | Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULTIA I his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G→A transition at codon 213, carries a significantly higher risk for women to develop breast cancer. We investigated the association between the SULT1A1 arg/his genotype and esophageal cancer in men, 187 cases of esophageal squamous cell carcinoma and 308 controls from 3 medical centers in Taiwan. Cigarette smoking, areca chewing and alcohol consumption were the major risks for developing esophageal cancer. The frequencies of arg/his in cases and controls were 27.8% (52/187) and 11.0% (34/308), respectively (p > 0.0001). No subjects carried his/his. After adjusting for substane use and other covariates, individuals with arg/his had a 3.53-fold higher risk (95% CI = 2.12-5.87) of developing esophageal cancer than those with arg/arg. Unexpectedly, this positive association was found to be even stronger (adjusted OR = 4.04-4.80) among non-smokers, non-drinkers or non-chewers. Our findings suggest that the SULT1A1 his213 allele is important in the development of esophageal cancer in men. ? 2002 Wiley-Liss, Inc. | - |
dc.relation.ispartof | International Journal of Cancer | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | arginine; histidine; protein SULT1A1; sulfotransferase; unclassified drug; adult; aged; alcohol consumption; allele; amino acid substitution; article; betel nut; cancer risk; cigarette smoking; clinical trial; controlled clinical trial; controlled study; covariance; disease course; enzyme polymorphism; esophagus carcinoma; genotype; human; major clinical study; male; multicenter study; priority journal; risk assessment; risk factor; squamous cell carcinoma; substance abuse; Adult; Aged; Aged, 80 and over; Alleles; Arylsulfotransferase; Carcinoma, Squamous Cell; Case-Control Studies; DNA Primers; Esophageal Neoplasms; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors; Smoking; Sulfotransferases | - |
dc.title | SULT1A1 polymorphism and esophageal cancer in males | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/ijc.10805 | - |
dc.identifier.pmid | 12455060 | - |
dc.identifier.scopus | 2-s2.0-0037211727 | - |
dc.relation.pages | 101-104 | - |
dc.relation.journalvolume | 103 | - |
dc.relation.journalissue | 1 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.orcid | 0000-0001-9727-227X | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學系 |
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