https://scholars.lib.ntu.edu.tw/handle/123456789/481691
標題: | Significance of P53 and Rb protein expression in surgically treated non- small cell lung cancers | 作者: | Lee Y.-C. YIH-LEONG CHANG Luh S.-P. JANG-MING LEE JIN-SHING CHEN |
公開日期: | 1999 | 出版社: | Elsevier Inc. | 卷: | 68 | 期: | 2 | 起(迄)頁: | 343-347 | 來源出版物: | Annals of Thoracic Surgery | 摘要: | Background. Alterations of the P53 or Rb gene are among the most frequently observed genetic changes in primary lung cancer. Nevertheless, there has been no final conclusion on the relationship between P53 or Rb protein expression and clinico-pathological parameters in primary lung cancer. A large-scale study was performed to examine the clinicopathological and prognostic significance of P53 and Rb expressions in 207 surgically resected non-small cell lung cancer (NSCLC) patients. Methods. Tumor specimens were obtained from 207 primary NSCLC surgically resected from January 1990 through December 1994. The avidin-biotin-peroxidase method was used to determine the expression of P53 or Rb of tumor cells using anti-P53 or anti-Rb monoclonal antibodies. The relationships between P53 or Rb protein expression and the clinicopathological parameters were analyzed. Results. Expression of P53 or Rb protein was detected in 115 (55.6%) and 136 (65.7%) of the 207 lung tumors, respectively. P53 had significantly higher positive results in patients with regional lymph node metastasis and advanced tumor stage. Rb expression was significantly lower in lung cancers with a macro- or microscopic picture of tumor necrosis. Additionally, an inverse correlation between the expression of Rb and P53 was found. By multiple variate analysis, P53 expression and pathological stage were independent, significant prognostic factors. Further analysis demonstrated P53 expression was an independent prognostic factor in stage 1, but not in other stages. Conclusions. P53 expression is especially useful as a prognostic factor in stage 1 lung cancer. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032736229&doi=10.1016%2fS0003-4975%2899%2900618-9&partnerID=40&md5=69a35fd9cec4df74e025baf31c545732 https://scholars.lib.ntu.edu.tw/handle/123456789/481691 |
ISSN: | 0003-4975 | DOI: | 10.1016/S0003-4975(99)00618-9 | SDG/關鍵字: | protein p53; adult; aged; cancer staging; conference paper; female; gene expression regulation; human; human tissue; immunohistochemistry; lung carcinogenesis; lung non small cell cancer; lung resection; lymph node metastasis; major clinical study; male; priority journal; prognosis; protein expression; tumor necrosis |
顯示於: | 醫學系 |
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