https://scholars.lib.ntu.edu.tw/handle/123456789/481786
標題: | Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study | 作者: | CHUEH-HUNG WU Chen L.-S. Yen M.-F. Chiu Y.-H. Fann C.-Y. Chen, Tony Hsiu Hsi SHIN-LIANG PAN |
公開日期: | 2014 | 出版社: | Public Library of Science | 卷: | 9 | 期: | 7 | 起(迄)頁: | e98158 | 來源出版物: | PLoS ONE | 摘要: | Background: Previous studies on the association between tuberculosis and the risk of developing ischemic stroke have generated inconsistent results. We therefore performed a population-based, propensity score-matched longitudinal follow-up study to investigate whether contracting non-central nervous system (CNS) tuberculosis leads to an increased risk of ischemic stroke. Methods: We used a logistic regression model that includes age, sex, pre-existing comorbidities and socioeconomic status as covariates to compute the propensity score. A total of 5804 persons with at least three ambulatory visits in 2001 with the principal diagnosis of non-CNS tuberculosis were enrolled in the tuberculosis group. The non-tuberculosis group consisted of 5804, propensity score-matched subjects without tuberculosis. The three-year ischemic stroke-free survival rates for these 2 groups were estimated using the Kaplan-Meier method. The stratified Cox proportional hazards regression was used to estimate the effect of tuberculosis on the occurrence of ischemic stroke. Results: During three-year follow-up, 176 subjects in the tuberculosis group (3.0%) and 207 in the non-tuberculosis group (3.6%) had ischemic stroke. The hazard ratio for developing ischemic stroke in the tuberculosis group was 0.92 compared to the non-tuberculosis group (95% confidence interval: 0.73-1.14, P = 0.4299). Conclusions: Non-CNS tuberculosis does not increase the risk of subsequent ischemic stroke. ? 2014 Wu et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84904664098&doi=10.1371%2fjournal.pone.0098158&partnerID=40&md5=e3a368a96c9330ce42402b54eba63fb6 https://scholars.lib.ntu.edu.tw/handle/123456789/481786 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0098158 | SDG/關鍵字: | adult; age; ambulatory care; article; brain ischemia; controlled study; female; follow up; gender; human; major clinical study; male; propensity score; risk factor; social status; survival rate; tuberculosis; aged; brain ischemia; complication; factual database; incidence; middle aged; propensity score; risk; Stroke; Taiwan; tuberculosis; Adult; Aged; Brain Ischemia; Databases, Factual; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Propensity Score; Risk; Stroke; Survival Rate; Taiwan; Tuberculosis |
顯示於: | 醫學系 |
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