https://scholars.lib.ntu.edu.tw/handle/123456789/481817
標題: | Is sarcopenia associated with hepatic encephalopathy in liver cirrhosis? A systematic review and meta-analysis | 作者: | KE-VIN CHANG Chen J.-D. WEI-TING WU KUO-CHIN HUANG Lin H.-Y. DER-SHENG HAN |
公開日期: | 2019 | 出版社: | Elsevier B.V. | 卷: | 118 | 期: | 4 | 起(迄)頁: | 833-842 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/purpose: Hepatic encephalopathy (HE), a major neuropsychiatric complication in advanced liver disease, is associated with poor prognosis. Sarcopenia, characterized by a decline in muscle mass, strength, and physical performance, is prevalent in liver cirrhosis. This study aims to explore whether sarcopenia is associated with HE in cirrhotic patients. Methods: PubMed and EMBASE were searched for relevant cohort and case-control studies investigating the association between sarcopenia and HE up to July 2018. Data of patients' characteristics, definition of low muscle mass, and protocols of grading/diagnosing HE were retrieved. The primary outcome was estimated by a pooled odds ratio (OR) and its 95% confidence interval (CI), using a random effect model. Results: The meta-analysis enrolled 6 studies, comprising 1795 patients. Sarcopenia was positively associated with the presence of HE (OR 2.74 with a 95% CI, 1.87 to 4.01). The association was less likely to be influenced by differences in research designs, focused study outcomes, muscle mass measurements, and protocols of grading/diagnosing HE. There was lack of evidence supporting higher serum ammonia levels in patients with sarcopenia. Conclusion: In patients with liver cirrhosis, there is a significant association between sarcopenia and HE. A greater number of prospective studies are necessary to clarify whether the association remains even after adjusting relevant confounders and to suggest effective prevention of HE in patients with coexisting sarcopenia. ? 2018 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054086952&doi=10.1016%2fj.jfma.2018.09.011&partnerID=40&md5=aea5f589e4d1981bba52e34b2abf906a https://scholars.lib.ntu.edu.tw/handle/123456789/481817 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2018.09.011 | SDG/關鍵字: | ammonia; ammonia; ammonia blood level; Article; case control study; clinical protocol; cohort analysis; disease association; Embase; hepatic encephalopathy; human; liver cirrhosis; Medline; methodology; muscle mass; outcome assessment; prospective study; risk assessment; sarcopenia; statistical bias; systematic review; blood; complication; hepatic encephalopathy; liver; liver cirrhosis; meta analysis; metabolism; sarcopenia; skeletal muscle; Ammonia; Hepatic Encephalopathy; Humans; Liver; Liver Cirrhosis; Muscle, Skeletal; Sarcopenia |
顯示於: | 醫學系 |
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