https://scholars.lib.ntu.edu.tw/handle/123456789/482581
標題: | Lysophosphatidic acid in prostate cancer progression | 作者: | Lin, Y.-C., Huang, Y.-L., Lee, H. HSINYU LEE |
關鍵字: | LPA receptor; Lysophosphatidic acid (LPA); Prostate cancer | 公開日期: | 2015 | 卷: | 4 | 期: | 5 | 起(迄)頁: | 527-536 | 來源出版物: | Translational Cancer Research | 摘要: | Human prostate cancer is a common cancer and the second leading cause of deaths due to cancer in American man. Although hormone therapy can successfully suppress tumor growth, cancer cells transform into hormone-refractory cells and adopt a highly malignant phenotype. Therefore, scientists are looking for better therapies for prostate cancer patients base on the characteristics of these cancer cells. Significant researches have found that the bioactive lipid lysophosphatidic acid (LPA) mediates prostate cancer progression including cell proliferation, survival, and migration. In this review, we summarize the pathological roles of LPA signals in prostate cancer. The characteristics of expression of LPA receptors and LPA-related enzymes in prostate cancer are also discussed. These reports suggest that targeting LPA signaling may develop as a novel therapy to against malignant prostate cancer in the future. ? 2011 - 2016 Translational Cancer Research. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/482581 | DOI: | 10.3978/j.issn.2218-676X.2015.10.05 | SDG/關鍵字: | enzyme; lysophosphatidic acid; lysophosphatidic acid receptor; lysophosphatidic acid related enzyme; unclassified drug; vasculotropin A; vasculotropin C; cancer growth; cell motility; cell proliferation; cell survival; human; lymphangiogenesis; male; metastasis; prostate cancer; prostate cancer cell line; protein expression; protein function; Review; signal transduction; tumor vascularization |
顯示於: | 生命科學系 |
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